共查询到20条相似文献,搜索用时 15 毫秒
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The development of advanced optical methods has played a key role in propelling progress in neurobiology. Genetically-encoded fluorescent molecules found in nature have enabled labeling of individual neurons to study their physiology and anatomy. Here we discuss the recent use of both native and synthetic optical highlighter proteins to address key problems in neurobiology, including questions relevant to synaptic function, neuroanatomy, and the organization of neural circuits. 相似文献
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Chemical genetics, or the specific modulation of cellular systems by small molecules, has complemented classical genetic analysis throughout the history of neurobiology. We outline several of its contributions to the understanding of ion channel biology, heat and cold signal transduction, sleep and diurnal rhythm regulation, effects of immunophilin ligands, and cell surface oligosaccharides with respect to neurobiology. 相似文献
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Vladimir V. Pravosudov Tom V. Smulders 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2010,365(1542):859-867
Many animals regularly hoard food for future use, which appears to be an important adaptation to a seasonally and/or unpredictably changing environment. This food-hoarding paradigm is an excellent example of a natural system that has broadly influenced both theoretical and empirical work in the field of biology. The food-hoarding paradigm has played a major role in the conceptual framework of numerous fields from ecology (e.g. plant–animal interactions) and evolution (e.g. the coevolution of caching, spatial memory and the hippocampus) to psychology (e.g. memory and cognition) and neurobiology (e.g. neurogenesis and the neurobiology of learning and memory). Many food-hoarding animals retrieve caches by using spatial memory. This memory-based behavioural system has the inherent advantage of being tractable for study in both the field and laboratory and has been shaped by natural selection, which produces variation with strong fitness consequences in a variety of taxa. Thus, food hoarding is an excellent model for a highly integrative approach to understanding numerous questions across a variety of disciplines. Recently, there has been a surge of interest in the complexity of animal cognition such as future planning and episodic-like-memory as well as in the relationship between memory, the environment and the brain. In addition, new breakthroughs in neurobiology have enhanced our ability to address the mechanisms underlying these behaviours. Consequently, the field is necessarily becoming more integrative by assessing behavioural questions in the context of natural ecological systems and by addressing mechanisms through neurobiology and psychology, but, importantly, within an evolutionary and ecological framework. In this issue, we aim to bring together a series of papers providing a modern synthesis of ecology, psychology, physiology and neurobiology and identifying new directions and developments in the use of food-hoarding animals as a model system. 相似文献
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Individual differences in emotion processing 总被引:11,自引:0,他引:11
Recent functional brain imaging studies of the neurobiology of emotion have investigated how individual differences among subjects modulate neural responses during emotion processing. Differences in personality, dispositional affect, biological sex, and genotype can all substantially modulate the neural bases of emotion processing in prefrontal, limbic, and other brain regions, across a variety of domains including emotional reactions, emotional memory, and emotion perception. Analysis of individual differences provides a new window into the neurobiology of emotion processing that complements traditional approaches. 相似文献
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The use of methods from contemporary nonlinear dynamics in studying neurobiology has been rather limited.Yet, nonlinear dynamics has become a practical tool for analyzing data and verifying models. This has led to productive coupling of nonlinear dynamics with experiments in neurobiology in which the neural circuits are forced with constant stimuli, with slowly varying stimuli, with periodic stimuli, and with more complex information-bearing stimuli. Analysis of these more complex stimuli of neural circuits goes to the heart of how one is to understand the encoding and transmission of information by nervous systems. 相似文献
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J. Allan Hobson 《Current opinion in neurobiology》1992,2(6):759-763
The most important recent work on the neurobiology of sleep has focused on the precise cellular and biochemical mechanisms of rapid eye movement sleep mediation. Direct and indirect evidence implicates acetylcholine-containing neurons in the peribrachial pons as critical in the triggering and maintenance of rapid eye movement sleep. Other new studies provide support for the hypothesis that the cholinergic generator system is gated during waking by serotonergic and noradrenergic influences. A growing consensus regarding the basic neurobiology has stimulated new thinking about the brain basis of consciousness during waking and dreaming. 相似文献
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Morris RG 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2003,358(1432):643-647
The discovery of long-term potentiation (LTP) transformed research on the neurobiology of learning and memory. This did not happen overnight, but the discovery of an experimentally demonstrable phenomenon reflecting activity-driven neuronal and synaptic plasticity changed discussions about what might underlie learning from speculation into something much more concrete. Equally, however, the relationship between the discovery of LTP and research on the neurobiology of learning and memory has been reciprocal; for it is also true that studies of the psychological, anatomical and neurochemical basis of memory provided a developing and critical intellectual context for the physiological discovery. The emerging concept of multiple memory systems, from 1970 onwards, paved the way for the development of new behavioural and cognitive tasks, including the watermaze described in this paper. The use of this task in turn provided key evidence that pharmacological interference with an LTP induction mechanism would also interfere with learning, a finding that was by no means a foregone conclusion. This reciprocal relationship between studies of LTP and the neurobiology of memory helped the physiological phenomenon to be recognized as a major discovery. 相似文献
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Mertz J 《Current opinion in neurobiology》2004,14(5):610-616
Nonlinear microscopy, a general term that embraces any microscopy technique based on nonlinear optics, is further establishing itself as an important tool in neurobiology. Recent advances in labels, labeling techniques, and the use of native or genetically encoded contrast agents have bolstered the capacity of nonlinear microscopes to image the structure and function of not just single cells but of entire networks of cells. Along with novel strategies to image over exceptionally long durations and with increased depth penetration in living brains, these advances are opening new opportunities in neurobiology that were previously unavailable. 相似文献
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Plant neurobiology: an integrated view of plant signaling 总被引:2,自引:0,他引:2
Brenner ED Stahlberg R Mancuso S Vivanco J Baluska F Van Volkenburgh E 《Trends in plant science》2006,11(8):413-419
Plant neurobiology is a newly focused field of plant biology research that aims to understand how plants process the information they obtain from their environment to develop, prosper and reproduce optimally. The behavior plants exhibit is coordinated across the whole organism by some form of integrated signaling, communication and response system. This system includes long-distance electrical signals, vesicle-mediated transport of auxin in specialized vascular tissues, and production of chemicals known to be neuronal in animals. Here we review how plant neurobiology is being directed toward discovering the mechanisms of signaling in whole plants, as well as among plants and their neighbors. 相似文献
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Huppert FA Baylis N 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2004,359(1449):1447-1451
Well-being: towards an integration of psychology, neurobiology and social science 相似文献
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The Neurobiology of Dopamine Signaling 总被引:5,自引:0,他引:5
Greengard P 《Bioscience reports》2001,21(3):247-269
The biochemistry of synaptic transmission, especially the neurobiology of dopamine signaling, is discussed. 相似文献
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Jack Price Paul J. Reber Michael Husser Paola Bezzi John N. Wood David S. Bredt Matthew Chafee Hugo Merchant Stephen Goodwin Bambos Kyriacou Gerd Kempermann Juergen Winkler 《Current opinion in neurobiology》2002,12(6):619
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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James Ashe Abdel El Manira Bambos Kyriacou Stephen F Goodwin Andrew Lumsden Susan Chapman Stefan Jungbluth Esther Bell Ana Coutinho Moheb Costandi Niels Adams Renee Dutton Mark Mayford Barbara Knowlton Michael Husser Venkatesh N Murthy John N Wood John A Assad Morgan Sheng Marie T Filbin Jin Qiu Eugene P Brandon Fred H Gage 《Current opinion in neurobiology》1999,9(6):645
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2001,11(2):135-143
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2001,11(5):523-530
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2000,10(4):423-432
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2000,10(5):529-538
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2000,10(1):1-12
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献
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《Current opinion in neurobiology》2001,11(4):395-404
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in neurobiology. 相似文献