Call for Papers Special Issue on “Biomarkers for Autoimmune Diseases”

正The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a specialissue(to be published in April of 2015)on the topic of"Biomarkers for Autoimmune Diseases".Autoimmune diseases(AIDs)are the third most common category of disease after cancer and heart disease and affect more than 5%of the general population.AIDs result from a complex interaction of genetic and epigenetic     

Special Issue on “Biomarkers for Autoimmune Diseases”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the summer of 2015)on the topic of‘‘Biomarkers for Autoimmune Diseases’’.Autoimmune diseases(AIDs)are the third most common category of disease after cancer and heart disease and affect more than 5%of the general population.AIDs result     

Call for Papers

正Special Issue on‘‘Biomarkers for Autoimmune Diseases’’The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in April of 2015)on the topic of‘‘Biomarkers for Autoimmune Diseases’’.Autoimmune diseases(AIDs)are the third most common category of disease after cancer and heart disease and affect more than 5%of the general population.AIDs result     

Autoimmune Diseases in the Bioinformatics Paradigm

<正>Autoimmune diseases(AIDs)consist of a group of physiological disorders with highly diversified pathogenesis and clinical manifestations[1],which affect more than 5%of the population worldwide[2].So far,the etiology of the AIDs is still poorly understood,whereas it is generally believed that autoimmune disorder results from a complex interaction of genetic and epigenetic variations,as well as triggering environmental factors[3].Because of the varied phenotypes in different individuals of one AID and sometimes shared     

Call for Papers Special Issue on “Biomarkers for Diseases”

正The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in June of 2015)on the topic of"Biomarkers for Diseases".As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,RNA,protein or metabolites,could gain highly     

Special Issue on“Biomarkers for Diseases”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2015)on the topic of‘‘Biomarkers for Diseases’’.As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,     

Special Issue on ‘‘Biomarkers for Diseases”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2015)on the topic of‘‘Biomarkers for Diseases’’.As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,RNA,protein or metabolites,could gain highly sensitive and specific signals that truly reflect     

Special Issue on‘‘Biomarkers for Diseases’’

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2015)on the topic of‘‘Biomarkers for Diseases’’.As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,RNA     

Biomarkers for Primary Sjgren's Syndrome

Primary Sjo¨gren's syndrome(p SS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of p SS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in p SS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjo¨gren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the Spring of 2017)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on ‘‘Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine''

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the Spring of 2017)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on ‘‘Biomarkers for Human Diseases and Translational Medicine'

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,     

Pluripotent Stem Cells Models for Huntington＇s Disease： Prospects and Challenges

Pluripotent cellular models have shown great promise in the study of a number of neurological disorders.Several advantages of using a stem cell model include the potential for cells to derive disease relevant neuronal cell types,providing a system for researchers to monitor disease progression during neurogenesis,along with serving as a platform for drug discovery.A number of stem cell derived models have been employed to establish in vitro research models of Huntington’s disease that can be used to investigate cellular pathology and screen for drug and cell-based therapies.Although some progress has been made,there are a number of challenges and limitations that must be overcome before the true potential of this research strategy is achieved.In this article we review current stem cell models that have been reported,as well as discuss the issues that impair these studies.We also highlight the prospective application of Huntington’s disease stem cell models in the development of novel therapeutic strategies and advancement of personalized medicine.     

Special Issue on ‘‘Biomarkers for Human Diseases and Translational Medicine'

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.Diagnosis upon biomarkers would aid in early and more efficient intervention,while prognostic     

Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease.     

Human enteric viruses–potential indicators for enhanced monitoring of recreational water quality

Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency(EPA) and the Centers for Disease Control and Prevention(CDC). Current recreational water standards rely on fecal indicator bacteria(FIB) levels as indicators of human disease risk. However present evidence indicates that levels of FIB do not always correspond to the presence of other potentially harmful organisms, such as viruses. Thus, enteric viruses are currently tested as water quality indicators, but have yet to be successfully implemented in routine monitoring of water quality. This study utilized enteric viruses as possible alternative indicators of water quality to examine 18 different fresh and offshore recreational waters on O‘ahu, Hawai‘i, by using newly established laboratory techniques including highly optimized PCR, real time PCR, and viral infectivity assays. All sample sites were detected positive for human enteric viruses by PCR including enterovirus, norovirus genogroups I and II, and male specific FRNA coliphage. A six time-point seasonal study of enteric virus presence indicated significant variation in virus detection between the rainy and dry seasons. Quantitative PCR detected the presence of norovirus genogroup II at levels at which disease risk may occur, and there was no correlation found between enteric virus presence and FIB counts. Under the present laboratory conditions, no infectious viruses were detected from the samples PCR-positive for enteric viruses. These data emphasize both the need for additional indicators for improved monitoring of water quality, and the feasibility of using enteric viruses as these indicators.