共查询到20条相似文献,搜索用时 46 毫秒
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Bradbury D Clarke D Seedhouse C Corbett L Stocks J Knox A 《The Journal of biological chemistry》2005,280(34):29993-30000
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Leukotactin-1 (Lkn-1)/CCL15 is a CC chemokine that binds to the CCR1 and CCR3. Lkn-1 functions as an essential factor in the
migration of monocytes, lymphocytes, and neutrophils. Although eosinophils express both receptors, the role of Lkn-1 in immature
eosinophils remains to be elucidated. In this present study, we investigated the contribution of the CCR1-binding chemokines
to chemotactic activity and in the differentiation in the human eosinophilic leukemia cell line EoL-1. Lkn-1 induced the stronger
migration of EoL-1 cells than other CCR1-binding chemokines such as RANTES/CCL5, MIP-1α/CCL3 and HCC-4/CCL16. Lkn-1-induced
chemotaxis was inhibited by pertussis toxin, an inhibitor of Gi/Go protein; U73122, an inhibitor of phospholipase C and rottlerin, an inhibitor of protein kinase C delta (PKCδ). Lkn-1 increased
PKCδ activity, which was partially blocked by the pertussis toxin and U73122. Lkn-1 enhanced the butyric acid-induced differentiation
via PKCδ after binding to the increased CCR1 because Lkn-1 caused EoL-1 cells to change morphologically into mature eosinophil-like
cells. Likewise, Lkn-1 increased the expression of both eosinophil peroxidase (EPO) and the major basic protein (MBP). PKCδ
activation due to Lkn-1 is involved in migration, as well as the butyric acid-induced differentiation. This finding contributes
to an understanding of CC chemokines in eosinophil biology and to the development of novel therapies for the treatment of
eosinophilic disorders. This study suggests the pivotal roles of Lkn-1 in the regulation of the movement and development of
eosinophils. 相似文献
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Nourbakhsh M Kalble S Dorrie A Hauser H Resch K Kracht M 《The Journal of biological chemistry》2001,276(6):4501-4508
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NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4 总被引:34,自引:0,他引:34
Helbig G Christopherson KW Bhat-Nakshatri P Kumar S Kishimoto H Miller KD Broxmeyer HE Nakshatri H 《The Journal of biological chemistry》2003,278(24):21631-21638
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Tanaka N Yonekura H Yamagishi S Fujimori H Yamamoto Y Yamamoto H 《The Journal of biological chemistry》2000,275(33):25781-25790
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Wu J Ling X Pan D Apontes P Song L Liang P Altieri DC Beerman T Li F 《The Journal of biological chemistry》2005,280(10):9745-9751
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Oda T Ueda A Shimizu N Handa H Kasahara T 《Journal of immunology (Baltimore, Md. : 1950)》2002,169(6):3329-3335
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Omori Y Imai J Watanabe M Komatsu T Suzuki Y Kataoka K Watanabe S Tanigami A Sugano S 《Nucleic acids research》2001,29(10):2154-2162