Study of the linear conversion of lower hybrid waves in the FT-1 tokamak by the enhanced time-of-flight scattering technique

The propagation of lower hybrid (LH) waves in a tokamak plasma in the presence of an LH resonance surface is studied experimentally with the use of a specially elaborated technique based on the backscattering of the probing microwave radiation in the upper hybrid resonance region. The technique provides resolution in the wave vectors of the scattering density fluctuations. The conditions are determined under which the LH wave propagates in accordance with the predictions of linear theory and is converted into the short-wave-length ion Bernstein mode. The parameter range is found in which the predictions of linear theory fail to hold and the nonlinear effects come into play during LH wave conversion. The radial wavelengths of the LH and ion Bernstein waves are determined.     

Parameters of turbulent structures at the periphery of the FT-2 tokamak

Results are presented from probe measurements carried out in the scrape-off layer of the FT-2 tokamak in the course of additional lower hybrid heating, during which an L-H transition was observed. The objective of this study was to obtain information on the parameters of blobs-turbulent structures with enhanced plasma density. The measurements were performed not only on the low-field side of the torus, but also on the high-field side, which is still poorly studied. Coherent structures with radial velocities directed both toward the vessel wall and into the plasma column were revealed at the tokamak periphery. Blobs propagating toward the vessel wall were found to prevail both before and after the L-H transition. The average radial velocity of blobs in the L- and H-modes was determined experimentally. The dependence of the radial blob velocity on the transverse size and density of the structure agrees with the ballooning mode model. It is found that the average value of the poloidal blob velocity is four to five times higher than the average radial velocity. The results of measurements carried out on both sides of the torus indicate the presence of internal poloidal polarization of blobs. The average drift velocity of such polarized structures is directed toward the vessel wall. The L-H transition is accompanied by a reduction in the radial velocity. At the same time, the average plasma density inside the structures observed on the low-field side increases appreciably during the transition. The obtained dependences of the radial blob velocity on the plasma density inside the structure generally agree with predictions of the ballooning mode model.     

Analysis of the efficiency of lower hybrid current drive in the FT-2 tokamak

Results are presented from experimental studies of the efficiency of lower hybrid current drive (LHCD) in the FT-2 tokamak. The dependence of the LHCD efficiency on the grill phasing Δφ and RF oscillator power was determined experimentally in a wide range of plasma densities. It is shown that, at high plasma currents (i.e., at sufficiently high electron temperatures), current drive is suppressed when the plasma density reaches its resonance value n _LH for the pumping wave frequency, rather than when parametric decay comes into play (as was observed in regimes with lower plasma currents and, accordingly, lower electron temperatures T _e ). In order to analyze the experimentally observed effect of LHCD and its dependence on the value and sign of the antenna phasing, the spectra of the excited LH waves, P(N _z ), were calculated. Simulations using the FRTC code with allowance for the P(N _z ) spectrum and the measured plasma parameters made it possible to calculate the value and direction of the LH-driven current, which are determined by the spectrum of the excited LH waves. It is shown that the synergetic effect caused by the interaction between different spectral components of the excited RF wave plays a decisive role in the bridging of the gap in the wave spectrum.     

CO2-laser radiation damage of the arterial wall

This study describes the effects of CO2 laser radiation on the histology of the normal rabbit arterial wall, using models that simulate laser angioplasty and anastomosis. Rabbit arteries were exposed to laser treatments similar to those used clinically; 40, 0.5 sec pulses of 40-60 mW, CO2 continuous wavelength laser, or a 1/2-circumferential laser anastomosis with a 60-80 mW continuous pulse. Aneurysms developed in 8 of 22 femoral, 1 of 22 carotid, and no controls at 12 week. There were small breaks in the internal elastic lamina with atrophy, loss of muscularis, "packing" of the elastica, thinning of the muscularis at the damage site, and enlargement of the arterial diameter. Aneurysms developed in one femoral and no carotid anastomosed artery. Laser anastomoses demonstrated more muscle damage and loss, with extensive scarring and a wider area of elastic loss than the controls. The intima was reestablished with focal reduplication of the internal elastic lamina. There were no histologic differences between the arteries which developed aneurysms and those which did not in either series. These results suggest that low power laser damage of the arterial wall consists mainly of destruction of the muscularis propria, with minimal damage to the elastica.     

Peripheral fluctuations and particle transport during an L-H transition in the FT-2 tokamak

Experimental data on the processes in edge plasma that accompany the transition to an improved confinement regime during lower hybrid heating in the FT-2 tokamak are presented. The poloidal and radial distributions of the plasma parameters and drift particle fluxes were measured with the use of mobile mulitielectrode Langmuir probes and were found to be substantially nonuniform in the poloidal direction. The evolution of the plasma parameters in the course of heating and during an L-H transition is investigated. It is shown that, in FT-2 experiments, the drift of plasma particles in a slowly varying (quasi-steady) electric field and the fluctuation-induced particle fluxes make comparable contributions to the radial particle transport, whereas the contribution of fluctuations to poloidal plasma fluxes is negligibly small. The effective coefficient of radial diffusion is determined. The measurement results show that the L-H transition is accompanied by a substantial decrease in this coefficient.     

Effect of the radial electric field on lower hybrid plasma heating in the FT-2 tokamak

Conditions for efficient ion heating in the interaction of lower hybrid waves with plasma are experimentally determined. Experiments show that efficient lower hybrid heating stimulates a transition to the improved confinement mode. The formation of internal and external transport barriers is associated with strong central ion heating, which results in a change of the radial electric field E _r and an increase in the shear of the poloidal plasma velocity. The improved confinement mode in the central region of the discharge is attained under the combined action of lower hybrid heating and an additional rapid increase in the plasma current. A new mechanism for the generation of an additional field E _r is proposed to explain the formation of a transport barrier.     

Investigation of statistical properties of peripheral fluctuations during an L-H transition in the FT-2 tokamak

The statistical properties of fluctuations of the plasma density and radial drift particle flux in the peripheral region of the FT-2 tokamak are analyzed using data from probe measurements. It is found that the probability distribution functions of the quantities under study vary over the radius and poloidal angle and change significantly after a transition to an improved confinement mode during auxiliary lower hybrid heating. Using experimental data and existing theoretical models, an analytic expression for the probability distribution function of the plasma density fluctuations is derived in a strongly nonlinear approximation. The expression is shown to agree well with experimental observations.     

Use of additional helium puffing for the diagnostics of plasma parameters at the FT-2 tokamak

The experiments carried out at the FT-2 tokamak in which additional pulsed puffing of helium into the hydrogen plasma was used for diagnostic purposes are considered. To estimate the necessary content of helium ions in the experiments on studying short-scale plasma oscillations, the ionization-recombination balance was simulated numerically under the assumption of a toroidally homogeneous influx of the working gas onto the boundary of the plasma column. In these simulations, the effective density of the neutral gas incident on the plasma boundary was determined by the iteration method, which made it possible to provide agreement between the obtained solution and the experimental discharge conditions. In particular, the correspondence of the determined admixture content to both the plasma quasineutrality condition and the value of the effective charge Z _eff, as well as agreement between the calculated and measured plasma density profiles, was ensured. The simulations were performed under the assumption of anomalous diffusion coefficients for all plasma components. The temporal variations of the ionization-recombination balance were checked by comparing them with the measured spectra of radiation in the HeI, HeII, and H_?? lines. In the current drive experiments, variations in n _e (r) at the discharge periphery were examined by the method based on the proportionality of the intensity ratio of the helium spectral lines, HeI(668 nm)/HeI(728 nm), to the plasma density. In these calculations, the factors relating the intensity ratio of these lines to the plasma density were taken from the literature on spectral diagnostics.     

Effect of pulsed CO2-laser irradiation on bone tissue

Different dynamic effects on biological tissue caused by pulsed laser radiation are described. It is shown that the parameters of these effects which take place on the bone tissue affected by pulsed CO2-laser radiation are directly dependent on the parameters of these pulses and may be predicted for any concrete application.     

Filtering molecular dynamics trajectories to reveal low-frequency collective motions: phospholipase A2

A novel method for analysing molecular dynamics trajectories has been developed, which filters out high frequencies using digital signal processing techniques and facilitates focusing on the low-frequency collective motions of proteins. These motions involve low energy slow motions, which lead to important biological phenomena such as domain closure and allosteric effects in enzymes. The filtering method treats each of the atomic trajectories obtained from the molecular dynamics simulation as a "signal". The trajectories of each of the atoms in the system (or any subset of interest) are Fourier transformed to the frequency domain, a filtering function is applied and then an inverse transformation back to the time domain yields the filtered trajectory. The filtering method has been used to study the dynamics of the enzyme phospholipase A2. In the filtered trajectory, all the high frequency bond and valence angle vibrations were eliminated, leaving only low-frequency motion, mainly fluctuations in torsions and conformational transitions. Analysis of this trajectory revealed interesting motions of the protein, including concerted movements of helices, and changes in shape of the active site cavity. Unlike normal mode analysis, which has been used to study the motion of proteins, this method does not require converged minimizations or diagonalization of a matrix of second derivatives. In addition, anharmonicity, multiple minima and conformational transitions are treated explicitly. Thus, the filtering method avoids most of the approximations implicit in other investigations of the dynamic behaviour of large systems.     

Raman spectroscopic study on low-frequency collective modes in self-associates of guanosine monophosphates

Low-frequency Raman spectra of the self-associates of guanosine monophosphates (GMPs) Na₂ · 5′GMP, K₂ · 5′GMP, Na₂ · 3′GMP, and K₂ · 3′GMP, and polyribonucleic acid K · poly(rG), were obtained. In acidic gels and dried fibers, GMP molecules are known to form helical stacks of hydrogen-bonded tetramers. Some low-frequency collective modes specific to the helically stacked structures were observed. We examined the dependence of these modes on counterions and water content. The lowest frequency mode at ca. 20 cm^?1 is sensitive to the water content of the sample and is clearly visible in solid-state samples, so it works as a marker band of the environmental condition of the helices. The intensity and the peak frequency of this mode in solid-state samples depend on the helical structure and counterions. The broad peaks in the vicinity of 100 cm^?1 are influenced by cations and are independent of water content.     

Effect of anomalous ion inertia and oblique ion viscosity on the radial electric field in FT-2 tokamak experiments

Results are presented from numerical simulations that show that, in a plasma with well-developed turbulence, the radial electric field can be positive in the region where the gradients of the plasma parameters are steep. In a plasma in which the turbulence is suppressed (as is the case with auxiliary lower hybrid heating), the radial electric field is found to exhibit a nearly neoclassical behavior during the formation of a transport barrier and transition to the H-mode.     

Dynamics of the electron thermal diffusivity at improved energy confinement during lower hybrid plasma heating in the FT-2 tokamak

The dynamics of electron heat transport at improved energy confinement during lower hybrid plasma heating in the FT-2 tokamak was studied experimentally. Evolution of the profiles of the electron temperature and density was thoroughly investigated under conditions of fast variation in the plasma parameters. The energy balance in the electron channel is calculated with the help of the ASTRA code by using the measured plasma parameters. Correlation is revealed between the dynamics of electron heat transport and the behavior of small-scale drift turbulence measured using the enhanced scattering correlation diagnostics. The suppression of heat transfer and turbulence agrees well with the increase in the shear of poloidal plasma rotation calculated from experimental data in the neoclassical approximation.     

Spectra of enhanced scattering by spontaneous density fluctuations in a tokamak

The wavenumber-resolved radar backscattering diagnostics in the upper hybrid resonance (UHR) region was used to study low-frequency short-scale turbulence in the FT-1 tokamak. The scattered spectra were measured for different delay times of the scattered signals. It is shown that the width of the spectrum of enhanced scattering by spontaneous fluctuations is proportional to the delay time. Possible mechanisms for the formation of the scattered spectra are proposed and discussed. The results of simulations and additional experiments were used to determine the dominant mechanisms governing the formation of the scattered spectra in the FT-1 tokamak. These mechanisms are related to the effect of multiple small-angle scattering of both the probing wave and the waves backscattered in the UHR region by long-scale density fluctuations and to the Doppler effect caused by the entrainment of short-scale fluctuations by the long-scale turbulent flow.     

Time evolution of the exponential wavenumber spectra of turbulence upon helium injection into a hydrogen discharge at the FT-2 tokamak

The effect of variations in the key parameter of short-wavelength turbulence—the ion-acoustic Larmor radius ρ _s , which determines the position of the maximum of the drift instability growth rate over poloidal wavenumbers—was studied experimentally at the FT-2 tokamak. For this purpose, helium was injected to hydrogen plasma, which resulted in a change in the electron temperature at the plasma edge. The universality of the exponential shape of the turbulence spectra over radial wavenumbers q and a substantial excess of the characteristic turbulence scale L over the ion-acoustic Larmor radius was confirmed with the help of correlative diagnostics of enhanced scattering. This excess at the discharge periphery reaches a value of 3–5 at a low electron temperature, apparently, due to an increase in the dissipation of drift waves upon their cascade transfer toward short scale-lengths.     

A study on the inactivation of micro-organisms and enzymes by high pressure CO2

This study addresses some microbial inactivation phenomena induced by high pressure CO2 over micro-organisms and enzymes. The activity of four selected enzymes was measured before and after treatment with CO2 under pressure in both buffer solutions and natural cellular environment (E. coli cells and tomato paste). Results are reported for acid phosphatase, alkaline phosphatase, ATPase, and pectinase at different conditions of temperature, CO2 pressure, and treatment time (32-40 degrees C, 85-150 bar, 30-70 min). The results obtained show that the high pressure CO2 treatment induces an inactivation of cellular enzymatic activity higher than the one caused on the same enzymes in solution. However, the measured activity difference is not caused by a damage at the enzymes molecular level but is a consequence of the permeabilization of the cellular envelopes which leads to a release of unmodified enzymes from the cells with simultaneous drop of enzymatic cellular activity. The reported data suggest that the bacterial cell death is probably due not to a selective effect of high pressure CO2 treatment but to simultaneous detrimental action of CO2 on cellular membrane and cell wall.     

Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study

A dynamic light scattering setup was used to study the undulations of freely suspended planar lipid bilayers, the so-called black lipid membranes, over a previously inaccessible range of frequency and wave number. A pure synthetic lecithin bilayer, 1,2-dielaidoyl-sn-3-glycero-phoshatidylcholine (DEPC), and binary mixtures of DEPC with 40 mol % of cholesterol, ergosterol, or lanosterol were studied. By analyzing the dynamic light scattering data (oscillation and damping curves) in terms of transverse shear motion, we extracted the lateral tension and surface viscosity of the composite bilayers for each sterol. Cholesterol gave the strongest increase in lateral tension (approximately sixfold) with respect to the DEPC control, followed by lanosterol (approximately twofold), and ergosterol (1.7-fold). Most interestingly, only cholesterol simultaneously altered the surface viscosity of the bilayer by almost two orders of magnitude, whereas the other two sterols did not affect this parameter. We interpret this unique behavior of cholesterol as a result of its previously established out-of-plane motion which allows the molecule to cross the bilayer midplane, thereby effectively coupling the bilayer leaflets to form a highly flexible but more stable composite membrane.     

Transition into the improved core confinement mode as a possible mechanism for additional electron heating observed in the lower hybrid current drive experiments at the FT-2 tokamak

In experiments on lower hybrid current drive (LHCD) carried out at the FT-2 tokamak, a substantial increase in the central electron temperature T _e (r = 0 cm) from 550 to 700 eV was observed. A complex simulation procedure is used to explain a fairly high LHCD efficiency and the observed additional heating, which can be attributed to a transition into the improved core confinement (ICC) mode. For numerical simulations, data obtained in experiments with deuterium plasma at 〈n _e 〉 = 1.6 × 10¹⁹ m^–3 were used. Simulations by the GRILL3D, FRTC, and ASTRA codes have shown that the increase in the density and central temperature is apparently caused by a significant suppression of heat transport in the electron component. The mechanism for transition into the improved confinement mode at r < 3 cm can be associated with the broadening of the plasma current channel due to the lower hybrid drive of the current carried by superthermal and runaway electrons. In this case, the magnetic shear s = (r/q)(dq/dr) in the axial region of the plasma column almost vanishes during the RF pulse. In this study, the effect of lower hybrid waves on the plasma parameters, resulting in a transition into the ICC mode, is considered. New experimental and calculated data are presented that evidence in favor of such a transition. Special attention is paid to the existence of a threshold for the transition into the ICC mode in deuterium plasma.