Motor systems

The field of motor control has broadened considerably over the past decade. Increasingly detailed information has accrued about the cellular and molecular processes involved in motor pattern generation and motor learning while, at the other extreme, the comparison of studies in humans and monkeys has begun to bridge the gap between cognitive and motor functions. The most striking feature of recent research has been the intense use of electrophysiological procedures in behaving monkeys and non-invasive imaging procedures in humans to elucidate details of sensory-motor transformations and the functional roles of different brain regions in the learning, planning and execution of movements.     

Motor systems Neurobiology of behaviour

A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Neurobiology.     

Motor systems: Neurobiology of behaviour

A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Neurobiology.     

Motor systems: Neurobiology of behaviour

A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Neurobiology.     

Motor program selection in simple model systems

In recent years, studies of molluscan and crustacean feeding circuits have greatly expanded our knowledge of how the nervous system selects specific behaviors. Increasing use of neurobehavioral studies, and examination of the roles of identified command-like or influential neurons have narrowed the gap between knowledge of circuit connectivity and understanding of the normal behavioral functions of these circuits.     

Motor systems: Neurobiology of behaviour: Web alert

A selection of World Wide Web sites relevant to the reviews published in this issue of Current Opinion in Neurobiology.     

Motor End-Plates

In the preparation of motor end-plates for class room work the use of sodium thiosulfate is suggested as a precaution against overstaining and as a regressive measure. Digestion of the connective tissue eliminates the tedious teasing and the possible destruction of the delicate nerve fibers. Mounting in a solution of gum arable makes the slides more durable than glycerin jelly for class use. Whole neuromuscular spindles may be obtained by this method.     

Tuning Multiple Motor Travel via Single Motor Velocity

Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport.     

细菌鞭毛马达——一种卓越的分子机器

鞭毛马达(flagellar motor)是一种分子旋转马达,它在细菌鞭毛的结构与功能中起着中心作用.鞭毛马达的结构已基本清楚,主要由Mot A、Mot B、Fli G、Fli M和Fli N 5种蛋白组成定子(stator)和转子(rotor),其驱动力来自于跨膜的H⁺或Na⁺流.目前对鞭毛马达的旋转动力学及旋转力矩产生机制已有初步的了解.鞭毛马达可作为研究分子旋转马达的理想模型,对其深入研究将有助于认识生物能量转化利用及细胞运动的机制并具有广泛的生物学意义.