Base excision repair: AP endonucleases and DNA polymerases

The DNA base lesions in living cells occur permanently and with high frequency as a result of the action of exogenous and endogenous factors. The main mechanism providing removal of such lesions is base excision repair.     

植物AP2/ERF类转录因子研究进展

植物AP2/ERF是一个庞大的转录因子基因家族,含有由60~70个氨基酸组成的AP2/ERF结构域而得名,存在于所有的植物中。AP2/ERF转录因子参与多种生物学过程,包括植物生长、花发育、果实发育、种子发育、损伤、病菌防御、高盐、干旱等环境胁迫响应等。AP2/ERF类转录因子参与水杨酸、茉莉酸、乙烯、脱落酸等多种信号转导途径,而且是逆境信号交叉途径中的连接因子。文章对国内外近年来有关植物AP2/ERF类转录因子的分类、生物学功能、基因调控等方面的研究进行了综述。     

WRKY transcription factors: evolution,regulation, and functional diversity in plants

Protoplasma - The recent advancements in sequencing technologies and informatic tools promoted a paradigm shift to decipher the hidden biological mysteries and transformed the biological issues...     

DNA conformation and its changes upon binding transcription factors

Pyrimidine-purine steps are flexible and can roll around the major groove. This feature is used to follow the protein surface and thereby create a particular superstructure of DNA. The interaction of the two molecules can be understood in terms of a close fitting of the two surfaces, in particular, how the DNA surface adapts to the protein surface. For analysing the fitting the widths of two DNA grooves are useful parameters.Much progress has been made since Schrödinger predicted “a gene to be an aperiodic solid (or a crystal)” (29) and we hope that our review may contribute in a small way.