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通过硅胶、ODS、Sephadex LH-20等多种柱色谱技术以及制备HPLC等对黄鹌菜(Youngia japonica)甲醇提取物进行分离,根据核磁波谱技术对分离的化合物进行结构鉴定。利用MTT法筛选影响三阴性乳腺癌(MDA-MB-231)细胞生长的化合物,进一步利用克隆形成实验,Hoechst33342/PI双染色法,Annexin V-FITC/PI双染以及Western blot检测候选化合物对乳腺癌和结直肠癌的抑制效果及可能的作用机制。从黄鹌菜中分离到5个单体化合物,经核磁共振谱鉴定为grosheimin (1),4-(3′-hydroxypropyl)-2,6-dimethoxyphnol-3′-O-β-D-glcoside (2),木犀草素-7-O-β-D-葡萄糖苷(3),木犀草素-7-O-β-D-葡萄糖醛酸苷(4),芹菜素(5)。通过活性筛选发现grosheimin能显著降低三阴性乳腺癌细胞MDA-MB-231的活力。明视野下观察到在不同浓度grosheimin处理下,MDA-MB-231和结直肠癌(HCT-116)细胞形态发生明显改变;grosheimin作用24 ... 相似文献
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Species nostra Y. lanatas Babcoc. et Stebbins affinis sed foliis glabris differt. Herba parva perennis, radice gracili, 1—1. 5 mm vel vix 1 mm in diametro. Caulisgracillimus, 3—5 cm altus, basi 0. 2—0. 3 mm in diametro, reliquiis petiolorum veterumbrunneis vel pallide nigrescentibus, simplex vel e basi 1-vel 2-ramosus, ramis pergracilibus 相似文献
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祁门过路黄和过路黄核型的比较研究 总被引:8,自引:0,他引:8
报道了祁门过路黄和过路黄的核型。前者核型公式为2n=2x=24=6m 6sin 6st 6t,为首次报道;后者核型公式为2n=2x=24=2m 4sm 6st 12t。与前人报道一致.并进一步对二者的核型进行比较分析。根据核型和外部形态特征的综合分析,祁门过路黄和过路黄的差异水平已明显超过种内变异水平,故将祁门过路黄独立出来,另立新种,是比较恰当的。 相似文献
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白叶香茶菜的化学成分 总被引:4,自引:0,他引:4
从白叶香茶菜(Rabdosia leucophylla(Dunn)Hara)地上部分的乙醇提取物中分离出5个化合物,根据其波谱分析并结合化学方法分别鉴定为:白叶香茶菜戊素(1)、白叶香茶菜己素(2)、信阳冬凌草甲素(3)、maslinic acid(4)和胡萝卜甙(5)。其中1和2为新化合物,2的结构还通过X-单晶衍射得到证实。 相似文献
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报道西藏一个新记录属,是睡菜科(Menyanthaceae)的莕菜属(Nymphoides),并报道该地区的一个新记录种,即莕菜(Nym phoides peltatum(Gmel.)O.Kuntze). 相似文献
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Stachyurus himalaicus ssp. purpureus Y. P. Zhu&Z. Y. Zhang,a new subspecies of Stachyuraceae from eastern Himalaya,is described. It differs from the typical subspecies,S. hi-malaicus ssp. himalaicus,by having purplish pink to dark purple flowers. The new subspecies oc-curs in Xizang(Tibet)of China,E Nepal,Sikkim,Bhutan,and NE India,usually growing in dense forests at an altitude between2200and3300m. 相似文献
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Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies 总被引:1,自引:0,他引:1
Myoelectrical activity was recorded in the proximal and distal colon of rabbits using chronically implanted electrodes. The motility in both the proximal and distal colon was inhibited by the intravenous (IV) administration of the following opioid agonists for mu receptors: morphine and fentanyl, kappa receptors: ethylketazocine (EKC) and U 50 488 H, and delta receptors: D-Ala2 D-Leu5-enkephalin (DADLE) and D-Ser2 Leu-enkephalin-Thr6 (DSLET). In contrast, the myoelectric activity in the distal colon was increased during the infusion of an endogenous kappa opioid agonist, dynorphin (DYN). All of these effects were prevented by naloxone pretreatment. During in vitro studies using extraluminal force transducers, fentanyl, U 50 488 H and DSLET inhibited spontaneous contractions of the proximal colon, but U 50 488 H and DSLET caused a substantial increase in the motility of the distal colon. The observed motor responses in the proximal and distal colon following opioid agonist administration indicate that the control of these two intestinal segments may be different. It is suggested that the stimulatory effect of dynorphin on the distal colon is peripherally-mediated while inhibition of the whole colon by opioid agonists regardless of subtypes seems to be centrally-mediated. 相似文献
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云南苞叶兰属一新种 总被引:2,自引:0,他引:2
孟连苞叶兰 新种 图 1BrachycorythismenglianensisY .Y .Qian ,sp .nov.(Trib .Orchideae ,Subtrib .Orchidi nae) . Fig.1SpeciesaffinisB .galeandrae (Rchb .f.)Summerh .,sedfloribusalbisvelpallidepur pureis,sepalis 5 nerviis,intermedioangusteovatoveloblongo ,1 2~ 1 3mmlongo ,4~ 4 .5mmla to ,eisl… 相似文献
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WEI Yi-Gang 《植物分类学报:英文版》2004,42(6):528-532
Paralagarosolen fangianum Y. G. Wei, a new genus and species of Gesneriaceae from Guangxi, China, is described and illustrated. Paralagarosolen Y. G. Wei is closely related to Lagarosolen W. T. Wang in having corolla tube cylindric, not swollen, and stigmas 2, but differs by having leaves sometimes peltate at base, cyme with only one flower, corolla lobes rounded-obtuse at apex, and capsule broadly ovoid-ellipsoid. 相似文献