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1.
C M Contreras L Chacón M L Marván M A Guzmán-Sáenz 《Boletín de estudios médicos y biológicos》1992,40(1-4):9-13
Antidepressants exert mixed actions on serotonergic and catecholaminergic systems. However, it is unknown whether a catecholaminergic blockade impinge on the actions of a tricyclic with serotonergic agonist properties (clomipramine) in limbic structures. The aim of the present study is to explore the effects of a catecholaminergic lesion in the basolateral amygdala on the firing rate of lateral septal, and hippocampal neurons in rats treated with clomipramine. An amygdaline lesion with 6-OHDA resembled the actions of clomipramine on the firing rate in lateral septal neurons, i.e. an increased rate of firing. However, the lesion blocked further effects of clomipramine on septal firing. Clomipramine decreased the firing rate in hippocampal neurons; however, neither the 6-OHDA lesion nor the added treatment with clomipramine modified the firing rate. It is concluded that an intact catecholaminergic amygdaloid input to lateral septal nuclei is necessary for clomipramine actions; however, the initial action of the tricyclic may involve a catecholaminergic blockade. 相似文献
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Kichigina VF Kutyreva ES Sudnitsyn VV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2003,53(6):754-765
It was shown by us earlier that bilateral intracerebroventricular injection of alpha2-adrenoreceptor agonist clonidine produced a dose-dependent effect on theta oscillations in the septohippocampal system of awake rabbits. A relatively low dose of clonidine (0.5 microgram) attenuated and a high dose (5 micrograms) significantly enhanced the rhythmic activity. It was suggested that the effect of the low dose of clonidine is mediated by presynaptic alpha2-adrenoreceptors were as postsynaptic alpha2-adrenoreceptors. In this article sensory neuronal responses in the medial septal area (MS) were analyzed against the background of the theta activity modulation by different clonidine doses. Different effects of the low and high doses of the agonist were revealed. The low dose of clonidine (0.5 microgram in 5 microliters into each lateral ventricle) which produced a decrease in the theta activity resulted in attenuation of excitation and enhancement of inhibition, i.e., the number of activating effects significantly decreased and inhibitory responses were more frequent and distinct. The high dose of clonidine (5 micrograms in 5 microliters) which produced a sharp increase in the theta activity led to a significant decrease in the reactions of the MS cells to sensory stimuli (from 76.8% in the control to 45% under clonidine) independently on the initial reaction character. Persisted excitatory and inhibitory responses became less distinct than the initial ones except single excitatory reactions. The results suggest that alpha2-adrenoreceptors are involved in the control of the sensory reactivity of MS neurons. A sharp decrease in neuronal reactivity during stable rhythmical oscillations developing under the influence of high dose of clonidine confirm the role of the theta rhythm in the septohippocampal system as an active filter in information selection and registration. 相似文献
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Responses of septal nuclei neurons to microiontophoretically administered putative neurotransmitters
M Segal 《Life sciences》1974,14(7):1345-1351
In halothane anesthetized rats, neurons of the medial and lateral septal nuclei were tested with iontophoretically applied putative neurotransmitters. GABA, norepinephrine, serotonin, and acelycholine in roughly this order of potency were inhibitory with respect to spontaneous and evoked activity of both medial and lateral septal nuclei cells. No specific effects of any of the compounds were observed on septal unit responses to fornix or fimbria stimulation. 相似文献
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Retrograde transport of fluorescent tracers (diamidino yellow and true blue) was used to study the arrangement of brainstem neurons innervating the lateral pterygoid muscle in the rat. The lateral pterygoid motoneurons were located in the dorsolateral (jaw-closing) part of the trigeminal motor nucleus with clear somatotopy in the caudal part of the nucleus. No muscle-related neurons were present in the mesencephalic trigeminal nucleus. Histological examination of serial sections of lateral pterygoid muscles confirms the notion that, at least in the rat, this muscle is devoid of muscle spindles. 相似文献
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《Cell reports》2023,42(4):112291
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9.
Structural and ultrastructural changes in the medial part of the ventral horn were studied in segments of the cat spinal cord following destruction of the ventral column at the level C1–C2. Analysis of results obtained by the Fink — Heimer method showed that degenerating preterminals occur mainly in Rexed's lamina VIII and also in ventromedial zones of lamina VII. Preterminals of descending pathways of the ventral column are also found in the intermediate nucleus of Cajal (central part of lamina VI) and in the ventromedial motor nucleus. Fewer of these preterminals are present in the thoracic and, in particular, in the lumbar segments. Staining by the Holländer — Vaaland method revealed degenerating myelinated axons of small diameter (3–5 µ), evidently collaterals of descending fibers entering the gray matter, in lamina VIII. Degenerative changes in myelinated axons may be manifested either as marked condensation and shrinking or as the appearance of numerous neurofilaments, polymembraneous structures, and cytolysomes. Degeneration also affects axon terminals (axo-dendritic, axo-somatic, and axo-axonal) with spherical or flattened synaptic vesicles. Counting the relative numbers of intact terminals of the various types and their comparison with the corresponding figures for normal animals shows that most connections of descending fibers with spinal neurons are axo-dendritic in character. No degenerating terminals were found on the soma of the "dark" neurons or their processes.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 4, No. 6, pp. 579–586, November–December, 1972. 相似文献
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Using the immunohistochemical method, serotoninergic neurons were identified in eight medulla nuclei in the bulbar vasomotor
centers of Wistar rats. Using morphometry, it was established that the proportion of serotoninergic neurons located in the
projection of the studied nuclei varied at 17–26%; the value of this parameter only reached 34–40% in nuclei of the posterior
raphe group. Single immunopositive cells able to perform integrative functions in the regulation of hemodynamics were identified
between the nuclei, as well as between nuclei and conducting pathways. 相似文献
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N. G. Gladkovich E. A. Lushchekina K. V. Shuleikina T. A. Leontovich 《Neurophysiology》1982,14(6):430-437
Five types of neurons were distinguished in the sensory nuclei of the trigeminal nerve, stained by Golgi's method, in kittens aged 1–5 days and 30 days: reticular and short-dendritic cells (with few branches), and multipolar giant cells, arborescent, and bushy neurons (densely branching). Yet another special type of cell, with a few short dendrites and one long dendrite, was distinguished in preparations from the brain of newborn kittens. Analysis of the dimensions of the bodies, the number, length, and ramification of the dendrites, and the total ramification of the cell yielded quantitative morphological characteristics of these neurons at different times of development. These types of neurons differed in their qualitative and quantitative parameters and in the features of their maturation.Bushy neurons underwent regressive changes during development. Foci of maximal ramification of dendrites of densely branched neurons changed their location during the first months of life relative to the cell body, moving into the more distal regions of the dendrites. Differences in orientation of dendrites with foci of maximal ramification were found relative to neighboring brain formations, which depended on the types of cells and the animal's age. The high level of maturity of trigeminal neurons at birth was demonstrated.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Brain Institute, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 14, No. 6, pp. 592–600, November–December, 1982. 相似文献
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A B Belousov O S Vinogradova P I Pakhotin 《Zhurnal evoliutsionno? biokhimii i fiziologii》1991,27(5):653-660
Spontaneous and evoked neuronal activity of the medical septum-diagonal band complex (MS-DB) has been investigated in slices from the brain of hibernating and active ground squirrels, as well as guinea pigs. In all experimental groups, the majority of the MS-DB neurones exhibited high regular of rhythmic burst spontaneous activity which persisted even after synaptic blockade in half of the neuronal population. Under the same conditions, the activity of the surrounding structures was completely suppressed. The density of the spontaneously active neurones in the slices, as well as the mean frequency of discharges in the MS-DB of hibernating ground squirrels, were significantly higher than in active ground squirrels and guinea pigs. Stimulation of the medial forebrain bundle evoked initial suppression of the activity in the majority of MS-DB units; in many of them, the suppression was followed by a burst discharge. Neurones with background rhythmic burst activity always reacted by resetting the spontaneous bursts. In total, 50-60% of the MS-DB neurones in active ground squirrels and guinea pigs reacted by post-inhibitory bursts, whereas in hibernating animals these responses were observed nearly in all neurones. Threshold values of the stimulating current were lower in hibernating animals; the intraburst density of spikes was increased. 相似文献
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O S Vinogradova E S Brazhnik 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1977,27(6):1166-1172
Investigation of neuronal activity on non-anaesthetized rabbits in non-stress chronic conditions revealed in the hippocampus a small proportion of neurones (10-12 percent) with a weak rhythmic (theta) modulation of their activity. In the medial and lateral septal nuclei this activity was more organized and was present in about one third of neuronal population. Disruption of septo-hippocampal connections completely abolished theta-rhythm in EEG and in neuronal activity of the hippocampus. Transection of the perforant path was followed by appearance of pronounced theta-bursts in a large group of neurones (38 percent in CA1 and 43 percent in CA3). Electrical stimulation of the hippocampus suppressed theta-bursts and decreased their frequency in the lateral spetal nucleus. Disruption of hippocampo-septal connections was followed by an increase of the population of septal neurones with theta-bursts (48 percent), which became more prounced. Some theoretical implications from these data concerning the nature of hippocampal theta-activity are discussed. 相似文献
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N. G. Gladkovich E. A. Lushchekina T. A. Leontovich K. V. Shuleikina 《Neurophysiology》1985,17(4):378-385
We have studied different types of neurons in the sensory trigeminal nuclei stained by the Golgi method in kittens aged 30 days with bilateral transection of the lingual nerve, made on the fifth postnatal day. We have shown that deprivation of afferent inflow from the tongue to trigeminal neurons leads to changes in the structure of all types of cells: reticular, arborescent, and bushy (68, 61, and 46% neurons respectively had changed), short-dendrite cells having changed to a lesser extent (16% changed neurons). The multipolar giant neurons hardly changed. The structural changes involved changes in the size of the bodies, number, length, and ramification of dendrites, and changes in their orientation and pattern of ramification, compared to the normal. We observed destructive changes resulting in a decrease in the quantitative parameters, and constructive changes resulting in an increase in the latter. Reticular and arborescent neurons showed both destructive and constructive changes, the short-dendritic neurons mainly constructive changes, and bushy neurons mainly destructive changes. The analysis of the differently directed rearrangements of the dendrite geometry in different types of deafferentated trigeminal neurons allowed us to put forward some proposals concerning the different functional role of these groups of cells in the system of afferent impulsation entering via the lingual nerve.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR. Institute of the Brain of the All-Union Research Center of Mental Health, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 17, No. 4, pp. 522–530, July–August, 1985. 相似文献
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V E Iakunin V V Amunts N Ia Kireeva 《Nauchnye doklady vysshe? shkoly. Biologicheskie nauki》1984,(4):49-54
The density of the reticular and respiratory neurones in the inspiratory and the exspiratory "points" of medial and lateral zones of the medulla oblongata the electrical stimulation of which is accompanied by the maximum inspiratory and exspiratory effects has been studied in the anesthetized cats. The electrophysiological and morphological data allow to relate the structures studied to the respiratory centre and confirm the correct picking out of two functionally heterogeneous zones - the medial and lateral. 相似文献
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It was shown that acoustic and immobilization stresses (developed due to a 2.5-h-long session of intensive, 100 dB, acoustic
influence and a 2-h-long session of soft fixation of the body and extremities, respectively) result in significant modifications
of the characteristics of background impulse activity of neurons of the nuclei of the rat amygdalar complex. Modifications
were greater in the lateral nucleus of the amygdala. Possible roles of some structures of the monoaminergic cerebral systems
in acute stress-related transformations of the impulse activity generated by neurons of the amygdalar complex are discussed.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 2, pp. 131–139, March–April, 2006. 相似文献
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F de Bilbao M C Senut J Sweeney F Jazat Y Lamour 《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1991,312(10):503-509
Age-related alterations in cued-training and place-training tasks were evaluated and compared to alterations in the galanin-like (GAL-LI) immunoreactive neurons in the medial septal area of the rat. Young adult (4 months) and aged (25-26 months) male Sprague-Dawley rats performed a modified version of the Morris water maze task. Immunohistochemical and morphometric techniques were used to analyse the distribution, density and morphology of GAL-LI neurons in the medial septum-diagonal band of Broca (MS-DBB) complex. A large variability in performance of the aged rats was evident, with the majority of aged rats exhibiting impaired performance on both parts of the task as compared to the young rats. In addition, there was a significant loss of GAL-LI cells in the MS-DBB complex, a significant reduction of the immunolabeling intensity of the subsisting GAL-LI cells and a non-statistically significant loss of septo-hippocampal GAL-LI neurons. There were no statistically significant correlations between the behavioral performances and the quantitative and qualitative modifications of GAL-LI cell bodies. 相似文献
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Mal'kov AE Karavaev EN Popova IIu Kichigina VF 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2007,57(5):618-623
Comparative investigation of activity of medial septal neurons, which was performed by extracellular recordings in the brain slices of health guinea pigs and in such ones of animals with the model of chronic temporal lobe epilepsy, revealed the distinctions between them, concerning a neuronal frequency and pattern of discharges. In the epileptic brain, twofold increase of general level of activity was observed comparative to control one, owing to augmentation of frequency of discharges in non-regular and regular non-bursting neurons. Sharp increase (three times as much) of number of cells with rhythmic burst discharges and changing of parameters of burst activity were discovered, the letter both in the neurons with endogenous (pacemaker) pattern and in the cells secondary involved in the rhythmic activity. Possible mechanisms of these alterations are discussed. The present data advance the understanding of the processes of a pathological synchronization and may promote creation of new approaches to treatment this disease. 相似文献