| 线粒体代谢与干细胞的命运决定 |
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| 引用本文： | 马明慧,马悦佼,孙婕,张海燕. 线粒体代谢与干细胞的命运决定[J]. 中华细胞与干细胞杂志(电子版), 2018, 8(3): 176-181. DOI: 10.3877/cma.j.issn.2095-1221.2018.03.010 |
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| 作者姓名： | 马明慧 马悦佼 孙婕 张海燕 |
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| 作者单位： | 1. 100069 北京，首都医科大学基础医学院2014级基础医学班专业；细胞生物学系 |
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| 基金项目： | 国家自然科学基金(81770616); 北京市自然基金(5172009); 首都医科大学本科生科技创新项目(XSKY2017) |
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| 摘 要： | 线粒体在真核细胞多种生物学过程中扮演重要角色，如能量产生、钙平衡、细胞内物质代谢、活性氧产生、细胞信号传导和凋亡等。线粒体的高度动态性，如生物发生、动态融合、分裂和退化等代谢特征与细胞种类、组织的需求密切相关。干细胞是一类具有自我更新和多向分化潜能的细胞。目前研究表明，线粒体的代谢与干细胞发育、命运决定紧密相关。本文综述干细胞干性维持及定向分化过程中，线粒体代谢改变与线粒体形态、结构和功能变化。
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| 关 键 词： | 线粒体 代谢 干细胞 细胞命运 决定 |
| 收稿时间： | 2017-11-26 |
Mitochondrial metabolism and stem cells fate |
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| Minghui Ma,Yuejiao Ma,Jie Sun,Haiyan Zhang. Mitochondrial metabolism and stem cells fate[J]. , 2018, 8(3): 176-181. DOI: 10.3877/cma.j.issn.2095-1221.2018.03.010 |
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| Authors: | Minghui Ma Yuejiao Ma Jie Sun Haiyan Zhang |
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| Affiliation: | 1. Grade 2014 for basic medical sciences, School of Basic Medical Science, Capital Medical University, Department of Cell Biology, Capital Medical University, Beijing 100069, China |
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| Abstract: | Mitochondria play fundamental roles in multiple processes in eukaryotic cells, including energy production, calcium homeostasis, intermediate metabolism, endogenous reactive oxygen species production, cell signaling, and apoptosis. In order to meet different demands of cell types and tissues, cells modulate mitochondrial function through biogenesis, degradation, dynamic fusion and fission events. Stem cells are defined by two key properties: self-renew and pluripotency. Studied show that the metabolism of mitochondria is closely related to the fate decision and the development of stem cells. Here, we review mitochondrial morphology, structure, function, and metabolic changes in the process of maintaining pluripotency of stem cells, and in the process of directed differentiation. |
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| Keywords: | Mitochondria Metabolism Stem cell Cell fate Determination |
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