Potassium permanganate–acridine yellow chemiluminescence system for the determination of fluvoxamine,isoniazid and ceftriaxone |
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| Authors: | Jafar Abolhasani Javad Hassanzadeh |
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| Affiliation: | Department of Chemistry, East Azerbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran |
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| Abstract: | Based on the oxidation of acridine yellow by permanganate in basic medium, a new chemiluminescence system was developed for the sensitive determination of some important drugs. The remarkable inhibiting effect of fluvoxamine, ceftriaxone and isoniazid on this reaction was applied to their detection. A possible mechanism was proposed for this system based on chemiluminescence emission wavelengths and experimental observations. Under optimum conditions, calibration graphs were obtained for 1 × 10?9 to 1 × 10?6 mol/L of fluvoxamine; 2 × 10?8 to 8 × 10?6 mol/L of ceftriaxone and 5 × 10?8 to 4 × 10?5 mol/L of isoniazid. This proposed method was satisfactorily used in the determination of these drugs in pharmaceutical samples and human urine and serum. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | chemiluminescence permanganate acridine yellow drug |
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