Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease |
| |
| Authors: | Choudhary Shailesh K Vrisekoop Nienke Jansen Christine A Otto Sigrid A Schuitemaker Hanneke Miedema Frank Camerini David |
| |
| Affiliation: | Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. |
| |
| Abstract: | Long-term asymptomatic human immunodeficiency virus (HIV)-infected individuals (LTA) usually have low viral load and low immune activation. To discern whether viral load or immune activation is dominant in determining progression to AIDS, we studied three exceptional LTA with high viral loads. HIV type 1 isolates from these LTA were as pathogenic as viruses from progressors in organ culture. Despite high viral loads, these LTA had low levels of proliferating and activated T cells compared to progressors, like other LTA. In contrast to those in progressors, HIV-specific CD4(+) T-cell responses in these LTA were maintained. Thus, low immune activation despite a high viral load preserved HIV-specific T-cell responses and resulted in a long-term asymptomatic phenotype. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
