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A mutation in Escherichia coli K-12 results in a requirement for thiamine and a decrease in L-serine deaminase activity |
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| Authors: | E B Newman B Miller L D Colebrook C Walker |
| Abstract: | Mutants of Escherichia coli K-12 deficient in L-serine deaminase (L-SD) activity have been isolated. These strains required thiamine and grew normally when it was provided. The decrease in L-SD activity caused no obvious metabolic deficiency. A study of revertants and transductants showed that a single mutation was responsible for the thiamine requirement and for the decrease in L-SD activity. |
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