Mollicellins: mutagenic and antibacterial mycotoxins. |
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| Authors: | A A Stark, B Kobbe, D Matsuo, G Bü chi, G N Wogan, A L Demain |
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| Affiliation: | A A Stark, B Kobbe, D Matsuo, G Büchi, G N Wogan, and A L Demain |
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| Abstract: | Eight mollicellins (depsidones) were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance. Two of them, mollicellins C and E, which contain a 3-methylbutenoic acid moiety, were mutagenic and bactericidal for Salmonella typhimurium in the absence of microsomes. Mollicellins D and F, each containing a chlorine atom, were bactericidal but not mutagenic. The mutagenic activity was completely abolished and the antibiotic activity was greatly reduced by coincubation with rat liver microsomes. |
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