| 建立正常人肺血管容量的无创精确测量方法的初步报告* |
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| 引用本文： | 孙兴国,Songshou Mao,Matthew J. Budoff,William W. Stringer,程显声. 建立正常人肺血管容量的无创精确测量方法的初步报告*[J]. 中国应用生理学杂志, 2015, 31(4): 326-329. DOI: 10.12047/j.cjap.0112.2015.007 |
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| 作者姓名： | 孙兴国 Songshou Mao Matthew J. Budoff William W. Stringer 程显声 |
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| 作者单位： | 1.中国医学科学院 北京协和医学院 国家心血管病中心阜外医院 心血管疾病国家重点实验室, 国家心血管疾病临床医学研究中心, 北京 100037; 2.美国加州大学洛杉矶分校Harbor-UCLA医学中心,洛杉矶生物医学研究院,圣约翰心血管研究中心,美国 加州90502 |
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| 基金项目： | *国家自然科学基金医学科学部面上项目（81470204）; 国家高新技术研究发展计划(863计划)课题(2012AA021009); 中国医学科学院国家心血管病中心科研开发启动基金（2012-YJR02) |
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| 摘 要： | 目的: 由于传统呼吸调控环路忽略了对血液循环的决定性作用,肺（静脉）血管容量相关研究甚少,亟需建立肺血管容量测量方法。方法: 选择正常志愿者完成CT全肺扫描,图像数据经过计算机软件分析处理,从肺尖到肺底以40~50层进行肺野手工切划,相邻层间由计算机自动模拟连接,在去除干扰后进行全肺血管（≥0.6 mm）高精度三维立体成像技术处理,进而计算全肺和肺血管容积。结果: 12例正常志愿者从肺尖到肺底CT扫描图片层数为530±98（431~841）张。全肺和肺血管的总容积是3705±857（2398~5383）ml ,肺血管血液总的容积是125±32（94~201）ml。按肺静脉系统血管容量约为全肺血管血液容量一半计算,应该是63±16（47~100）ml。结论: 肺CT扫描数据分析三维立体成像建立肺血管容量无创测量方法精确可行。
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| 关 键 词： | 肺脏CT扫描 肺血管总容量 肺血管树 肺静脉血管容量 |
| 收稿时间： | 2015-06-05 |
Preliminary reports of noninvasive accurate method to measure pulmonary vascular capacity in normal volunteers |
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| SUN Xing-guo,MAO Song-shou,BUDOFF MJ,STRINGER WW,CHENG Xian-sheng. Preliminary reports of noninvasive accurate method to measure pulmonary vascular capacity in normal volunteers[J]. Chinese journal of applied physiology, 2015, 31(4): 326-329. DOI: 10.12047/j.cjap.0112.2015.007 |
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| Authors: | SUN Xing-guo MAO Song-shou BUDOFF MJ STRINGER WW CHENG Xian-sheng |
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| Affiliation: | 1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Research Center of Clinic Medicine for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; 2. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California at Los Angeles, St. John's Cardiovascular Research Center, California 90502, USA |
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| Abstract: | Objective: Because the traditional loop of breathing control and regulation effect on blood circulation, there was rare study of pulmonary vein capacity.We need a noninvasive and accurate pulmonary vascular capacity measurement and analysis method. Methods: Twelve normal volunteers were performed a total lung CT scan, image data analysis processing by computer software, the whole lungs from the apex to the base of lung with 40~50 layers by hand-cut, the connection between adjacent layers automatically by a computer simulation, the full pulmonary vascular (≥0.6 mm) were treated by high-accuracy three-dimensional imaging technology after removing the interference, and then calculate the whole lung and pulmonary vascular. Results: The whole lung of the 12 normal volunteers from the apex to the base of lung CT scan image layers was 530±98(range, 431~841). The total capacity of lung and pulmonary vascular blood was 3705±857(range, 2398~5383)ml, and the total volume of the pulmonary vascular blood was 125±32(range, 94~201)ml. The pulmonary vein vascular blood volume was 63±16(range, 47~100)ml. Conclusion: The method of measuring the three-dimensional imaging of pulmonary vascular capacity by analyzing lung CT scan data is available and accurate. |
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| Keywords: | lung CT scan total capacity of the pulmonary vascular pulmonary vascular tree pulmonary vein blood volume |
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