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Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals |
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| Authors: | JV?Chamary,Laurence?D?Hurst author-information" > author-information__contact u-icon-before" > mailto:l.d.hurst@bath.ac.uk" title=" l.d.hurst@bath.ac.uk" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK |
| Abstract: | BackgroundIn mammals, contrary to what is usually assumed, recent evidence suggests that synonymous mutations may not be selectively neutral. This position has proven contentious, not least because of the absence of a viable mechanism. Here we test whether synonymous mutations might be under selection owing to their effects on the thermodynamic stability of mRNA, mediated by changes in secondary structure. |
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