Growth Rate-Dependent Accumulation of RNA from Plasmid-Borne rRNA Operons in Escherichia coli |
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| Authors: | Bradley S. Stevenson and Thomas M. Schmidt |
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| Affiliation: | Department of Microbiology and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824 |
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| Abstract: | Inadequate regulation of the expression of additional plasmid-borne rRNA operons in Escherichia coli was exaggerated at slow growth rates, resulting in increases of approximately 100% for RNA concentration and 33% for doubling time. These observations are consistent with the hypothesis that multiple rRNA operons constitute a metabolic burden at slow growth rates. |
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