Nature of the pressor substance in rabbit placenta |
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| Authors: | M. Ziegler B. Riniker F. Gross |
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| Affiliation: | Chirurgische Universitätsklinik, Heidelberg, Germany;Research Laboratories of the Pharmaceutical Department of Ciba Ltd., Basle, Switzerland |
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| Abstract: | 1. The renin-like substance isolated from the placenta of the rabbit produces a prolonged increase of blood pressure in the nephrectomized rat. If incubated with renin substrate from ox serum, it forms a pressor substance that elevates blood pressure in exactly the same way as does angiotensin. 2. This angiotensin-like principle was concentrated by means of ion-exchange chromatography and compared with Val-5-angiotensins I and II in two paper-chromatography systems and in paper electrophoresis. 3. In all the three methods the unknown principle behaved like a mixture of the two reference compounds. 4. It is concluded that incubation of the renin-like substance of placental origin with substrate from ox serum gave a mixture of Val-5-angiotensins I and II. This is evidence that the enzyme isolated from the placenta is either closely related to, or identical with, renin. |
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