Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model |
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| Authors: | Niizuma Takahiro Zerboni Leigh Sommer Marvin H Ito Hideki Hinchliffe Stewart Arvin Ann M |
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| Affiliation: | Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA. |
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| Abstract: | We generated an ORF65 deletion mutant by using a cosmid system constructed from the genome of a low-passage clinical isolate (P-Oka). Using the SCID-hu mouse model, we demonstrated that the ORF65 protein is dispensable for viral replication in skin and T cells, which are critical host cell targets during primary varicella-zoster virus infection. |
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