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Evidence for a major dominance component in the variation of serum pepsinogen I levels |
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| Authors: | J. I. Rotter F. L. Wong I. M. Samloff K. Varis M. Siurala T. Ihamaki A. Ellis R. B. McConnell |
| Abstract: | We report here a variance component analysis of the distribution of serum pepsinogen I levels in normal individuals, using a maximum-likelihood method on entire pedigrees. The results indicate a broad heritability of 91%, with some 74% being attributed to a dominance component. This is consistent with the hypothesis that the pepsinogen I level in normals is principally determined by the action of major genes, as also seems to be the case for duodenal ulcer patients and families. |
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