Modifying oligoalanine conformation by replacement of amide to ester linkage |
| |
| Authors: | Takahiro Hongen Tohru Taniguchi Kenji Monde |
| |
| Affiliation: | Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan |
| |
| Abstract: | Oligo(lactic acid) is an ester‐analogue of short oligoalanine sequence and adopts a rigid left‐handed helical structure. In this study, oligo(lactic acid) was incorporated into oligoalanine sequences and their conformations were studied by vibrational circular dichroism and electronic circular dichroism spectroscopy. The results suggested that oligo(lactic acid) moiety in these sequences maintains a left‐handed helix and increases the conformational propensity of the oligoalanine moiety to form a left‐handed polyproline type II‐like helix. The importance of the chirality of oligo(lactic acid) moiety for the oligoalanine conformation was also studied. The results obtained in this study should be useful in developing ester‐containing oligopeptides that function better than normal peptides. |
| |
| Keywords: | electronic circular dichroism lactic acid polyproline type II helix vibrational circular dichroism β ‐strand |
|
