A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation |
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| Authors: | Persuh Marjan Mandic-Mulec Ines Dubnau David |
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| Affiliation: | Public Health Research Institute, New York, New York 10016, USA. |
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| Abstract: | ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation. |
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