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| 益生菌辅助四联疗法对H. pylori感染患者根治效果及肠道菌群的影响 | |
| 引用本文： | 王梅, 王冬英, 寿嫣妮. 益生菌辅助四联疗法对H. pylori感染患者根治效果及肠道菌群的影响[J]. 中国微生态学杂志, 2022, 34(11): 1330-1333, 1337. doi: 10.13381/j.cnki.cjm.202211015 |
| 作者姓名： | 王梅 王冬英 寿嫣妮 |
| 作者单位： | 1. 药剂科，杭州市第一人民医院城北院区（杭州市老年病医院），浙江 310000; 2. 内科，杭州市第一人民医院城北院区（杭州市老年病医院），浙江 310000 |
| 摘 要： | 研究益生菌辅助四联疗法对 选择2019年1月至2020年6月在我院接受治疗的160例 观察组患者的 双歧杆菌四联活菌片辅助标准铋剂四联疗法治疗可显著提高 |
| 关 键 词： | 双歧杆菌四联活菌片 幽门螺杆菌 肠道菌群 炎性因子 根除率 |
| 收稿时间： | 2021-05-17 |
| 修稿时间： | 2022-09-01 |
Effect of probiotics combined with quadruple drug therapy on the eradication and intestinal flora in patients with H. pylori infection |
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| WANG Mei, WANG Dong-ying, SHOU Yan-ni. Effect of probiotics combined with quadruple drug therapy on the eradication and intestinal flora in patients with H. pylori infection[J]. Chinese Journal of Microecology, 2022, 34(11): 1330-1333, 1337. doi: 10.13381/j.cnki.cjm.202211015 | |
| Authors: | WANG Mei WANG Dong-ying SHOU Yan-ni |
| Affiliation: | 1. Department of Pharmacy, Chengbei District of Hangzhou First People's Hospital (Hangzhou Geriatric Hospital), Hangzhou, Zhejiang 310000, China |
| Abstract: | Objective To observe the effect of probiotics combined with quadruple drug therapy on the eradication and intestinal flora in patients with H. pylori infection. Methods A total of 160 patients with H. pylori infection in our hospital from January 2019 to June 2020 were randomly divided into control group (n = 80) or observation group (n = 80). The control group was treated with standard bismuth quadruple drug, while the observation group was treated with quadruple viable Bifidobacterium tablets. The eradication rate, recurrence rate, incidence of adverse reactions, clinical symptoms (epigastric pain, epigastric distension, belching, anorexia), intestinal flora (Bifidobacterium, Lactobacillus) and inflammatory factors (IL-6, IL-8 and TNF-α) were compared between the two groups. Results The eradication rate of H. pylori in the observation group was higher (95.00% vs 82.5%), while the recurrence rate and incidence of adverse reactions were lower (all P＜0.05). After treatment, the clinical symptom scores in the two groups significantly decreased, and those in the observation group were lower (all P＜0.05). After treatment, the counts of intestinal Bifidobacterium and Lactobacillus in the observation group increased, while those in the control group decreased. The counts of intestinal Bifidobacterium and Lactobacillus in the observation group were higher (all P＜0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the observation group were lower (P＜0.05). Conclusion Quadruple viable Bifidobacterium tablets combined with standard bismuth quadruple therapy in the treatment of H. pylori infection can significantly improve the eradication rate of H. pylori, reduce the recurrence rate and the incidence of adverse reactions, improve the distribution of intestinal flora, and reduce the clinical symptoms and inflammatory state of patients. |
| Keywords: | Bifidobacterium quadruple viable tablets Helicobacter pylori Intestinal flora Inflammatory factors Eradication rate |
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