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| 急性脑卒中患者肠道菌群研究 | |
| 引用本文： | 徐晓松, 蔡祥胜, 李瑞莹, 等. 急性脑卒中患者肠道菌群研究[J]. 中国微生态学杂志, 2022, 34(5): 562-566. doi: 10.13381/j.cnki.cjm.202205013 |
| 作者姓名： | 徐晓松 蔡祥胜 李瑞莹 官煜彬 陈小明 |
| 作者单位： | 广东药科大学附属第一医院检验科，广东 广州 510080 |
| 摘 要： | 通过粪便标本检测急性脑卒中患者肠道菌群变化情况, 探讨急性脑卒中患者肠道菌群结构。 通过高通量二代测序技术对10例健康者(对照组)及10例急性脑卒中患者(疾病组)粪便样本进行菌群结构测序分析。 与对照组比较, 急性脑卒中患者粪便样本中物种OTU信息量显著增加( 急性脑卒中患者肠道菌群结构与健康人存在显著差异。 |
| 关 键 词： | 急性脑卒中 肠道菌群 二代测序 |
| 收稿时间： | 2020-11-27 |
| 修稿时间： | 2021-12-11 |
Gut flora in patients with acute stroke |
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| XU Xiao-song, CAI Xiang-sheng, LI Rui-ying, et al. Gut flora in patients with acute stroke[J]. Chinese Journal of Microecology, 2022, 34(5): 562-566. doi: 10.13381/j.cnki.cjm.202205013 | |
| Authors: | XU Xiao-song CAI Xiang-sheng LI Rui-ying GUAN Yu-bin CHEN Xiao-ming |
| Affiliation: | Department of Clinical Laboratory, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China |
| Abstract: | ObjectiveTo explore the distribution and changes of gut flora in patients with acute stroke through fecal specimen detection, and discuss the composition of gut flora in the patients.MethodsTen healthy individuals(control group) and 10 patients with acute stroke(disease group) were enrolled. The intestinal flora were analyzed by using high-throughput second-generation sequencing.ResultsCompared with the control group, the number of OTU information in the gut flora of acute stroke patients increased significantly(P < 0.01); the diversity index(Shannon) and species homogeneity index(Evenness) also increased, but with no statistical differences(all P > 0.05). Compared with the control group, the abundance of Bacteroidetes increased significantly and that of Firmicutes decreased significantly(all P < 0.05). Compared with the normal control group, the abundances of Bacteroides, Bilophila and Butyricimonas increased significantly, however, those of Collinsella, Coprococcus and Clostridium decreased significantly(all P < 0.05).ConclusionThe composition of gut flora in acute stroke patients was significantly different from that in healthy people. |
| Keywords: | Acute stroke Gut flora Second-generation sequencing |
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