Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice. |
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| Authors: | J Allison Y L Zhang M G Parker |
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| Affiliation: | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. |
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| Abstract: | We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression. |
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