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Evidence that latent collagenases are enzyme-inhibitor complexes. |
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| Authors: | A Sellers E Cartwright G Murphy J J Reynolds |
| Abstract: | Specific collagenase from the culture media of various rabbit tissues and cells exists in active and latent forms. Latent collagenase is most effectively activated with 4-aminophenylmercuric acetate, a thiol-blocking reagent, strongly suggesting that latent forms are enzyme-inhibitor complexes. A collagenase inhibitor from bone cultures, which may be closely related to the inhibitor of such latent enzyme complexes, was partially characterized. |
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