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Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization |
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| Authors: | Hidekazu Higashide Seiko Ishihara Mika Nobuhara Yasuo Ihara Satoru Funamoto |
| Affiliation: | 1. Laboratory of Cognition and Aging, Graduate School of Brain Science, Doshisha University, Kyoto, Japan;2. Department of Neuropathology, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan |
| Abstract: | |
| Keywords: | Alzheimer disease amyloid‐β dimerization enzyme processing gamma‐secretase transmembrane domain |