Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region |
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| Authors: | Roche-Hakansson Hazeline Chatzidaki-Livanis Maria Coyne Michael J Comstock Laurie E |
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| Affiliation: | Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA. |
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| Abstract: | The activity of a fourth conserved tyrosine site-specific recombinase (Tsr) of Bacteroides fragilis was characterized. Its gene, tsr19, is adjacent to mpi, encoding the global DNA invertase regulating capsular polysaccharide biosynthesis. Unlike the other described Tsrs of B. fragilis, Tsr19 brings about inversion of two DNA regions, one local and one located distantly. |
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