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Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
Authors:Valdes Ana M  Loughlin John  Timms Kirsten M  van Meurs Joyce J B  Southam Lorraine  Wilson Scott G  Doherty Sally  Lories Rik J  Luyten Frank P  Gutin Alexander  Abkevich Victor  Ge Dongliang  Hofman Albert  Uitterlinden André G  Hart Deborah J  Zhang Feng  Zhai Guangju  Egli Rainer J  Doherty Michael  Lanchbury Jerry  Spector Tim D
Affiliation:1 Twin Research Unit, St. Thomas' Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK
2 University of Oxford, Institute of Musculoskeletal Sciences, Oxford OX3 7LD, UK
3 Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne NE1 7RU, UK
4 Myriad Genetics, Inc., Salt Lake City, UT 84108, USA
5 Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015 GE, The Netherlands
6 School of Medicine & Pharmacology, University of Western Australia and Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009 WA, Australia
7 Academic Rheumatology, University of Nottingham, City Hospital Nottingham, Nottingham NG5 1PB, UK
8 Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Leuven 3000, Belgium
9 Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
10 Department of Epidemiology & Biostatistics, Erasmus MC Rotterdam, Rotterdam 3015 GE, The Netherlands
Abstract:Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p < 1 x 10(-5) were estimated to have probabilities of being false positives
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