Sequence conservation and antigenic variation of the structural proteins of equine rhinitis A virus |
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| Authors: | Varrasso A Drummer H E Huang J A Stevenson R A Ficorilli N Studdert M J Hartley C A |
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| Affiliation: | Centre for Equine Virology, School of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. |
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| Abstract: | The nucleotide and deduced amino acid sequences of the P1 region of the genomes of 10 independent equine rhinitis A virus (ERAV) isolates were determined and found to be very closely related. A panel of seven monoclonal antibodies to the prototype virus ERAV.393/76 that bound to nonneutralization epitopes conserved among all 10 isolates was raised. In serum neutralization assays, rabbit polyclonal sera and sera from naturally and experimentally infected horses reacted in a consistent and discriminating manner with the 10 isolates, which indicated the existence of variation in the neutralization epitopes of these viruses. |
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