Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2 |
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| Authors: | Nishimura Hitoshi Yajima Toshiki Kagimoto Yoshiko Ohata Mutsuhiro Watase Taketo Kishihara Kenji Goshima Fumi Nishiyama Yukihiro Yoshikai Yasunobu |
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| Affiliation: | Division of Host Defense, Medical Institute for Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. |
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| Abstract: | Mice depleted of gammadelta T cells by in vivo administration of anti-TCRgammadelta monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the gammadelta T-cell-depleted mice. Mice deficient in the Vdelta1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial gammadelta T cells bearing Vdelta1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response. |
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