Fast noninvasive functional diffuse optical tomography for brain imaging |
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| Authors: | Hao Yang Jianbo Tang Paul R. Carney Huabei Jiang |
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| Affiliation: | 1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida;2. Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FloridaPresent addressHuabei Jiang has recently joined the Department of Medical Engineering at the University of South Florida. |
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| Abstract: | Advances in epilepsy studies have shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, it has been challenging to noninvasively detect these changes in real time and in humans, due to the lack of fast functional neuroimaging tools. In this study, we present a functional diffuse optical tomography (DOT) method with the guidance of an anatomical human head atlas for 3‐dimensionally mapping the brain in real time. Central to our DOT system is a human head interface coupled with a technique that can incorporate topological information of the brain surface into the DOT image reconstruction. The performance of the DOT system was tested by imaging motor tasks‐involved brain activities on N = 6 subjects (3 epilepsy patients and 3 healthy controls). We observed diffuse areas of activations from the reconstructed [HbT] images of patients, relative to more focal activations for healthy subjects. Moreover, significant pretask hemodynamic activations were also seen in the motor cortex of patients, which indicated abnormal activities persistent in the brain of an epilepsy patient. This work demonstrates that fast functional DOT is a valuable tool for noninvasive 3‐dimensional mapping of brain hemodynamics.  |
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| Keywords: | diffuse optical tomography functional brain imaging noninvasive brain imaging |
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