Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production |
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| Authors: | Taylor R Travis Bresnahan Wade A |
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| Affiliation: | Department of Microbiology, University of Minnesota, 1060 Mayo Building, MMC196, Minneapolis, MN 55455, USA. |
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| Abstract: | The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMV infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMV infection, identifying IE2 as an IFN-beta antagonist. |
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