Evaluation of the energetic contribution of an ionic network to beta-sheet stability |
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| Authors: | Lassila Kirsten S Datta Deepshikha Mayo Stephen L |
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| Affiliation: | Biochemistry Option, California Institute of Technology, MC 147-75, Pasadena, California 91125, USA. |
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| Abstract: | We have evaluated the interaction energy of a three-residue ionic network constructed on the beta-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by 0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol). |
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| Keywords: | β-Sheet protein stability protein design electrostatics side chain interactions |
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