| 河南省76 698例体检人群心肺功能检查结果与分析* |
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| 引用本文： | 张娜,孙兴国,赵桂华,徐金义,台文琦,谢燕清,李秋楠,陈嘉楠. 河南省76 698例体检人群心肺功能检查结果与分析*[J]. 中国应用生理学杂志, 2021, 37(1): 59-64. DOI: 10.12047/j.cjap.0104.2021.106 |
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| 作者姓名： | 张娜 孙兴国 赵桂华 徐金义 台文琦 谢燕清 李秋楠 陈嘉楠 |
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| 作者单位： | 1.郑州大学附属人民医院河南省人民医院,河南 郑州 450003;2.国家心血管病中心,中国医学科学院阜外医院,北京协和医学院心血管疾病国家重点实验室,心血管疾病国家临床医学研究中心,北京 100037;3.广州医科大学第一附属医院,广东 广州 510120 |
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| 基金项目： | *国家高技术研究发展计划（863计划）课题资助项目（2012AA021009）; 国家自然科学基金医学科学部面上项目（81470204）; 中国康复医疗机构联合重大项目基金（20160102）; 中国医学科学院国家心血管病中心阜外医院科研开发启动基金（2012-YJR02）; 首都临床特色应用研究与成果推广（Z161100000516127）; 北京康复医院2019-2021科技发展专项（2019-003）; 北京协和医学院教学改革项目（2018E-JG07）; 北京协和医学院-国家外国专家局外国专家项目（2015,2016,T2017025,T2018046,G2019001660）; 重庆市卫计委医学科研计划项目（2017MSXM090）; 重庆市科委社会事业与民生保障科技创新专项项目（cstc2017shmsA130063） |
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| 摘 要： | 目的: 肺功能和心电图检查是心肺运动试验（CPET）人体心肺代谢整体功能评估不可或缺的组成部分,本研究对肺通气功能、换气功能和小气道功能异常及其临床相关特征进行分析。方法: 采用横断面研究方法对2016年1月至2019年l2月在河南省人民医院就诊76 698例体检人员行常规心电图、肺通气和换气功能检查,比较不同性别、年龄组心肺功能异常检出率,进一步分析心肺功能异常严重程度的特点。结果: ①在76 698例常规心电图异常检出率为71.04%。②肺通气功能异常检出率36.86％,其中男性44.78％（17 570/39 237）,女性28.57％（10 703/ 37 461）,男性显著高于女性（P<0.01）,且各年龄段男性检出率均高于女性（P均<0.01）。③小气道功能异常检出率为56.26％,男性57.73%（22 661/39 237）,女性54.72％（20 499/37 461）,不同性别比较,差异有统计学意义（P<0.01）,其中30~39岁组,40-49岁组女性检出率高于男性（P均<0.05）,20~29岁组,50~59岁组,60~69岁组,≥70岁组均男性高于女性（P<0.05）。④换气功能异常检出率为28.54％,其中男性30.55％（7 433/24 327）,女性26.50％（5 507/20 780）,二者差异有统计学意义（P<0.05）;30~39岁组（P<0.05）、20~29岁组和40~49岁组（P均>0.05）,检出率女性高于男性,50~59岁组,60~69岁组,≥70岁组,男性检出率均高于女性（P均<0.05）。结论: 河南体检人群心功能、肺通气功能、换气功能及小气道功能异常的检出率较高,男性明显大于女性,年龄≥70岁者高于其他年龄段。
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| 关 键 词： | 肺通气功能 心电图 流行病学研究 换气功能 小气道功能减低 |
| 收稿时间： | 2020-08-12 |
Results and analysis of pulmonary function examination in 76 698 cases of physical examination crowd in Henain Province |
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| ZHANG Na,SUN Xing-guo,ZHAO Gui-hua,XU Jin-yi,TAI Wen-qi,XIE Yan-qing,LI Qiu-nan,CHEN Jia-nan. Results and analysis of pulmonary function examination in 76 698 cases of physical examination crowd in Henain Province[J]. Chinese journal of applied physiology, 2021, 37(1): 59-64. DOI: 10.12047/j.cjap.0104.2021.106 |
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| Authors: | ZHANG Na SUN Xing-guo ZHAO Gui-hua XU Jin-yi TAI Wen-qi XIE Yan-qing LI Qiu-nan CHEN Jia-nan |
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| Affiliation: | 1. Henan Provincial People's Hospital,Zhengzhou 450003;2. Department of Cardiology,Fuwai Hospital,Chinese Academy of Medical Sciences/National Center for Cardiovascular Diseases/ State Key Laboratory of Cardiovascular Diseases/Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100037;3. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China |
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| Abstract: | Objective: Pulmonary function testing (PFT) and electrocardiograph (ECG) are the vital components of the cardiopulmonary exercise test (CPET). This study is to investigate clinical characteristics of abnormal PFT as pulmonary ventilation dysfunction, small airway dysfunction and gas exchange (diffusion) dysfunction. Methods: Across-sectional study was conducted The 76 698 outpatient subjects who received health examination from December 2016 to February 2019 in Henan Provincial People's Hospital were recruited. The results of the ECG, PFT were compared among different sex and age sub-groups. Then the severity of their impaired PFT were analyzed. Results: Among 76 698 subjects, 39 237 subjects were male and 37 461 subjects were female. There were total 71.04% patients with abnormal ECG. There were total 28 273 (36.86%) patients with abnormal pulmonary ventilation function. The 17 570 patients (44.78%) (17 570/39 237) were male, 10 703 patients (28.57%) (10 703/37 461) were female, both the number and percentage of abnormal pulmonary ventilation function in male was significantly more than these in female (P<0.01). The percentage detectable rates of male were significant higher than that of female in all the different age sub-groups: 20~29, 30~39, 40~49, 50~59, 60~69 and ≥70 year (P<0.01). The total detectable abnormal rate of small airway dysfunction were 43 160 and 56.26% (43 160/76 698). The 57.73% (22 661/39 237) in male was significantly higher than 54.72% (20 499/37 461) in female (x2=74.87, P<0.01). The detectable abnormal rate of small airway dysfunction in male were lower than female in 30~39 year and 40~49year sub-groups (P<0.05), but were significantly higher in 20~29, 50~59, 60~69, and ≥70 yr sub-groups (P<0.05). Abnormal gas exchange (diffusion) dysfunction were detected in 28.54% (12 940/45 107) subjects. They were 7 433 (30.55%) in male,and 5 507 (26.50%)in female with significant gender difference (P<0.05). The abnormal diffusion detectable rate in 30~39 year sub-group was significant higher in female than in male (P<0.05), and were slightly higher without significant difference in 20~29 and 40~49 year sub-groups (P>0.05), but were significant lower in female than male in 50~59, 60~69 and ≥70 year sub-groups (P<0.05). Conclusion: The abnormal detectable rates in ECG, pulmonary ventilation dysfunction, gas exchange dysfunction and small airway dysfunction were higher in male than female, and higher in elder ≥70 year subgroup than all other younger age subgroups. |
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| Keywords: | pulmoonary ventilation functiion electrocardiogram epidemiological studies ventilation function reduced small airway function |
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