| Affiliation: | (1) Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel;(2) School of Computer Science, Tel-Aviv University, Tel-Aviv, 69978, Israel |
| Abstract: | Background In recent years, intensive computational efforts have been directed towards the discovery of promoter motifs that correlate with mRNA expression profiles. Nevertheless, it is still not always possible to predict steady-state mRNA expression levels based on promoter signals alone, suggesting that other factors may be involved. Other genic regions, in particular 3' UTRs, which are known to exert regulatory effects especially through controlling RNA stability and localization, were less comprehensively investigated, and deciphering regulatory motifs within them is thus crucial. |
