The emergence of shape: notions from the study of the Drosophila tracheal system |
| |
| Authors: | Casanova Jordi |
| |
| Affiliation: | Institut de Biologia Molecular de Barcelona (CSIC), Institut de Recerca Biomèdica, Carrer Josep Samitier 1-5, 08028, Barcelona, Spain. jcrbmc@cid.csic.es |
| |
| Abstract: | The generation of bodies and body parts with specific shapes and sizes has been a longstanding issue in biology. Morphogenesis in general and organogenesis in particular are complex events that involve global changes in cell populations in terms of their proliferation, migration, differentiation and shape. Recent studies have begun to address how these synchronized changes are controlled by the genes that specify cell fate and by the ability of cells to respond to extracellular cues. In particular, a notable shift in this research has occurred owing to the ability to address these issues in the context of the whole organism. For such studies, the Drosophila tracheal system has proven to be a particularly appropriate model. Here, my aim is to highlight some ideas that have arisen through our studies, and those from other groups, of Drosophila tracheal development. Rather than providing an objective review of the features of tracheal development, I intend to discuss some selected notions that I think are relevant to the question of shape generation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
