Older rhesus macaque infants are more susceptible to oral infection with simian-human immunodeficiency virus 89.6P than neonates |
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| Authors: | Chenine Agnès-Laurence Ferrantelli Flavia Hofmann-Lehmann Regina Vangel Mark G McClure Harold M Ruprecht Ruth M |
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| Affiliation: | Department of Cancer Immunology, Dana-Farber Cancer Institute, 44 Binney Street, JFB809, Boston, MA 02115-6084, USA. |
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| Abstract: | Earlier primate studies revealed that oral transmission of immunodeficiency viruses can occur at all ages [R. M. Ruprecht et al., J. Infect. Dis. 179(Suppl. 3):S408-S412, 1999]. Using a stock of pathogenic simian-human immunodeficiency virus, SHIV89.6P, we compared the 50% animal infectious dose needed to achieve systemic infection after oral challenge in newborn and older infant or juvenile rhesus macaques. Unexpectedly, the older monkeys required a 150-fold-lower virus challenge dose than the neonates (P=3.3 x 10(-5)). In addition, at least 60,000 times more virus was needed to achieve systemic infection in neonates by the oral route than by the intravenous route (P <1 x 10(-5)). Thus, route of inoculation and age are important determinants of SHIV89.6P infectivity in rhesus macaques. |
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