Bacterial superantigen exposure after resolution of influenza virus infection perturbs the virus-specific memory CD8(+)-T-cell repertoire |
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| Authors: | Huang Chiu-Chen Shah Sangeeta Nguyen Phuong Altman John D Blackman Marcia A |
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| Affiliation: | Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. |
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| Abstract: | Heterologous viral infections have been shown to impact the preexisting memory CD8(+)-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococcal enterotoxin B, a bacterial superantigen, causes a selective functional deletion of cross-reactive influenza virus-specific CD8(+) memory T cells. This perturbation of the memory repertoire can have a significant impact on viral clearance after secondary challenge. |
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