| 山羊房颤模型中左心房与肺静脉外膜碎裂电位的动态比较 |
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| 引用本文： | 李健,时向民,郭红阳,林琨,国建萍,王玉堂,单兆亮. 山羊房颤模型中左心房与肺静脉外膜碎裂电位的动态比较[J]. 中国应用生理学杂志, 2021, 37(3): 235-239. DOI: 10.12047/j.cjap.6037.2021.011 |
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| 作者姓名： | 李健 时向民 郭红阳 林琨 国建萍 王玉堂 单兆亮 |
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| 作者单位： | 解放军总医院第一医学中心心内科, 北京 100853 |
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| 基金项目： | *军队保健专项课题(17BJZ08) |
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| 摘 要： | 目的:比较在持续性房颤发生、发展过程中,房颤模型山羊左心房与肺静脉外膜碎裂电位(CFAEs)的变 化,以期探讨肺静脉外膜碎裂电位(CFAEs)在持续性房颤中的作用.方法:选取10只雌性山羊,使用左心房快速刺激,发送输出电压为6 V、周长为20 ms的脉冲1 s,间隔2 s后重复发放,以此方法建立持续性房颤模型(房颤持续...
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| 关 键 词： | 心房纤颤 心外膜电位 左心房 肺静脉 山羊 |
Dynamic comparisons of epicardial electrograms between the left atrium and pulmonary veins in atrial fibrillation in goat model |
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| LI Jian,SHI Xiang-min,GUO Hong-yang,LIN Kun,GUO Jian-ping,WANG Yu-tang,SHAN Zhao-liang. Dynamic comparisons of epicardial electrograms between the left atrium and pulmonary veins in atrial fibrillation in goat model[J]. Chinese journal of applied physiology, 2021, 37(3): 235-239. DOI: 10.12047/j.cjap.6037.2021.011 |
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| Authors: | LI Jian SHI Xiang-min GUO Hong-yang LIN Kun GUO Jian-ping WANG Yu-tang SHAN Zhao-liang |
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| Affiliation: | Department of Cardiology, 1st Medical Center, General Hospital of PLA, Beijing 100853, China |
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| Abstract: | Objective: To compare epicardial electrograms between the left atrium (LA) and pulmonary veins (PVs) dynamically at development of persistent atrial fibrillation(AF) in goats PVs. Methods: Ten female goats were instrumented with electrodes at the LA and left side PV. Sustained AF (＞24 h) was induced in the goat by rapid intermittent left atrial pacing for(9.5±2.3)days at a pacing interval of 20 ms for 1 s with a maximum output of 6.0 V, followed by a 2-s period without pacing. Characteristics of PVs and LA epicardial electrograms were analyzed in the development of AF. Results: With prolonged stimulation, the duration of AF was prolonged, complex fractionated atrial electrograms(CFAEs) in LA and was increased gradually, PVs had more CFAEs than LA all the time. When induced AF lasted for more than 24 h, CFAEs in PVs became sustained approximately (2.7%±3.6% vs 92.6%±6.4%, at onset of AF vs AF lasted for more than 24 h, P＜0.05), and the ratio of CFAEs in PVs was more than that in LA (92.6%±6.4% vs 72.8%±5.3%, P＜0.05). Conclusion: The epicardial CFAEs are in specific area, which increase along with electrical remodeling. The epicardial CFAEs may play an important role in the maintenance of AF in this model. |
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| Keywords: | atrial fibrillation epicardial electrograms pulmonary vein left atrium goat |
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