| 槐花散白头翁汤合用对急性放射性直肠炎大鼠的治疗作用及其机制研究 |
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| 引用本文： | 赵杨,张玉双,王玉祥,张明,史会娟,李晶. 槐花散白头翁汤合用对急性放射性直肠炎大鼠的治疗作用及其机制研究[J]. 中国应用生理学杂志, 2021, 37(3): 313-317. DOI: 10.12047/j.cjap.6052.2021.016 |
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| 作者姓名： | 赵杨 张玉双 王玉祥 张明 史会娟 李晶 |
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| 作者单位： | 1. 河北医科大学中西医结合学院, 2. 河北医科大学第四医院中医科,3. 河北省人民医院, 石家庄 050017 |
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| 摘 要： | 目的:观察槐花散合白头翁汤对大鼠急性放射性直肠炎(ARP)的疗效.方法:选用清洁级SD大鼠40只,随机分为空白组(Control)、模型组(Model)、美沙拉嗪组(Mesalazine)、槐花散合白头翁汤组(Formula),每组10只.除Control组外其他三组大鼠盆腔均接受6MV-X射线20 GY剂量照射,制作...
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| 关 键 词： | 槐花散 白头翁汤 急性放射性直肠炎 大鼠 NF-κB ICAM-1 VCAM-1 |
Effects of Huaihuasan and baitouweng formular on rats with acute radiation proctitis and its mechanism |
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| ZHAO Yang,ZHANG Yu-shuang,WANG Yu-xiang,ZHANG Ming,SHI Hui-juan,LI Jing. Effects of Huaihuasan and baitouweng formular on rats with acute radiation proctitis and its mechanism[J]. Chinese journal of applied physiology, 2021, 37(3): 313-317. DOI: 10.12047/j.cjap.6052.2021.016 |
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| Authors: | ZHAO Yang ZHANG Yu-shuang WANG Yu-xiang ZHANG Ming SHI Hui-juan LI Jing |
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| Affiliation: | 1. College of Integrated Chinese and Western Medicine, Hebei Medical University, Department of Traditional Chinese Medicine,2. The Fourth Hospital of Hebei Medical University,3. Department of Oncology, Hebei General Hospital, Shijiazhuang 050017, China |
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| Abstract: | Objective: To investigate the effects of huaihuasan and baitouweng formular on acute radiation proctitis (ARP) in rats. Methods: Forty clean grade SD rats were randomly divided into control group, model group, mesalazine group and formula group. Except the control group, all the other three groups received 6 MV-20 GY dose of X-ray irradiation in the pelvic cavity, and the rat model of acute radiation proctitis was established. The rats were given daily gavage intervention with the corresponding drugs after mold formation. According to the adult clinical equivalent dose (body surface area), the control group and the model group were given 10 ml/kg saline daily, the Mesalazine group was treated with Mesalazine solution at the dose of 0.27 g/kg, and the Formular group was given (0.91 g/kg) respectively for 14 days. All rats were killed on the 14th day after administration. To evaluate the general situation of the rats, HE staining was used to observe the pathological changes in the rectal tissues of the rats. The contents of intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) were detected by Elisa, and the expression of NF-κb P65 in the tissues were detected by Western blot. Results: Compared with the model group, in the mesalazine group and the formular group, the clinical symptoms and intestinal mucosal healing of rats were improved significantly, the expression level of NF-κB P65 protein in the rectal tissues and the serum contents of ICAM-1 and VCAM-1 were decreased with statistically significant differences (P＜0.05). Conclusion: Huaihuasan and baitouweng formular can reduce NF-κB, ICAM-1 and VCAM-1 to improve symptoms and rectal mucosal injury in ARP rats. |
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| Keywords: | Huaihuasan Baitouweng formular acute radiation proctitis rat NF-κB ICAM-1 VCAM-1 |
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