Synthesis of Indolyldiketopiperazines with NBS |
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| Authors: | Yangmin Ma Decheng Ren Hao Wu Jin Zhang Tingting Feng Yanchao Li |
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| Affiliation: | 1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi'an, China;2. WuXiAppTec (Tianjin) Co., Ltd., TEDA, Tianjin, China;3. Pharmaron (Xi'an) Co., Ltd., Xi'an, China;4. Northwest Institute of Nonferrous Metals, Xi'an, China |
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| Abstract: | Two series of indolyldiketopiperazines were synthesized starting from methyl 1‐substituted‐1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylate hydrochlorides via N‐bromo‐succinimide (NBS) as an important reagent. All eight compounds were characterized by nuclear magnetic resonance (NMR) and elemental analysis. Furthermore, the mechanisms of NBS‐reacted rearrangements are also discussed. Chirality 26:790–792, 2014. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | N‐bromosuccinimide conjugative effect indolyldiketopiperazine rearrangement |
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