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Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity |
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| Authors: | Arsalan S. Haqqani George Thom Matthew Burrell Christie E. Delaney Eric Brunette Ewa Baumann Caroline Sodja Anna Jezierski Carl Webster Danica B. Stanimirovic |
| Affiliation: | 1. National Research Council of Canada, Human Health Therapeutics Research Centre, Ottawa, ON, Canada;2. Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, UK |
| Abstract: | |
| Keywords: | affinity optimization blood– brain barrier intracellular trafficking quantitative targeted proteomics transferrin receptor antibody |