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Microinjection of ras p21 induces a rapid rise in intracellular pH. |
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| Authors: | N Hagag J C Lacal M Graber S Aaronson M V Viola |
| Abstract: | Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also. |
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