Quality‐of‐life outcomes in patients with advanced melanoma: A review of the literature |
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| Authors: | Karen A. Malkhasyan Yousef Zakharia Mohammed Milhem |
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| Affiliation: | 1. Department of Internal Medicine, Division of General Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA;2. Department of Internal Medicine, Division of Hematology and Medical Oncology, University of Iowa Hospitals and Clinics and Holden Comprehensive Cancer Center, Iowa City, IA, USA |
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| Abstract: | For patients with metastatic melanoma, the emergence of immune checkpoint inhibitors and targeted BRAF and MEK inhibitors has markedly enhanced clinical outcomes compared with chemotherapy. However, these novel agents are also associated with unique sets of adverse events, and increased overall survival can lead to prolonged exposure to some novel agents. Therefore, clinical evaluation of these therapies has now included the analysis of health‐related quality of life (HRQoL) in addition to more traditional efficacy and safety outcomes as a measure of patient perception of benefit. The current review focuses on HRQoL outcomes in clinical trials of immune checkpoint inhibitors and targeted therapies in patients with advanced and metastatic melanoma to inform healthcare providers about patient perception of HRQoL as a new perspective in treatment decision making. |
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| Keywords: | immunotherapy melanoma quality of life targeted therapy |
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