Predicting domain-domain interactions using a parsimony approach |
| |
| Authors: | Katia S Guimarães Raja Jothi Elena Zotenko Teresa M Przytycka |
| |
| Affiliation: | Katia S Guimarães, Raja Jothi, Elena Zotenko, and Teresa M Przytycka |
| |
| Abstract: | We propose a novel approach to predict domain-domain interactions from a protein-protein interaction network. In our method we apply a parsimony-driven explanation of the network, where the domain interactions are inferred using linear programming optimization, and false positives in the protein network are handled by a probabilistic construction. This method outperforms previous approaches by a considerable margin. The results indicate that the parsimony principle provides a correct approach for detecting domain-domain contacts. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
