Rab 5 is required for the cellular entry of dengue and West Nile viruses |
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| Authors: | Krishnan Manoj N Sukumaran Bindu Pal Utpal Agaisse Herve Murray James L Hodge Thomas W Fikrig Erol |
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| Affiliation: | Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center for Medical Research and Education, 300 Cedar Street, New Haven, CT 06520-8031, USA. |
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| Abstract: | The mechanisms of cellular entry of dengue and West Nile viruses are not well characterized. We show that both these viruses enter HeLa cells by clathrin-dependent endocytosis and require vacuolar acidic pH. Inhibition of the GTPase Rab 5 or 7, which regulates transport to early or late endosomes, respectively, demonstrated that Rab 5 was essential for survival of both dengue and West Nile virus. These data broaden our understanding of the pathways required for productive dengue and West Nile virus infection and may facilitate new strategies for combating disease. |
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