Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis |
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| Authors: | Martín Javier Samoilovich Elena Dunn Glynis Lackenby Angie Feldman Esphir Heath Alan Svirchevskaya Ekaterina Cooper Gill Yermalovich Marina Minor Philip D |
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| Affiliation: | Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom. jmartin@nibsc.ac.uk |
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| Abstract: | The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described. Virus 31043 had a Sabin-derived type 3-type 2-type 1 recombinant genome with a 5'-end crossover point within the capsid coding region. The result was a poliovirus chimera containing the entire coding sequence for antigenic site 3a derived from the Sabin type 2 strain. The recombinant virus showed altered antigenic properties but did not acquire type 2 antigenic characteristics. The significance of the presence in nature of such poliovirus chimeras and the consequences for the current efforts to detect potentially dangerous vaccine-derived poliovirus strains are discussed in the context of the global polio eradication initiative. |
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