Cochlioquinone Derivatives with Apoptosis‐Inducing Effects on HCT116 Colon Cancer Cells from the Phytopathogenic Fungus Bipolaris luttrellii L439 |
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| Authors: | Lu‐Wei He Jun‐Jie Han Quan Chen Lei Cai Hong‐Wei Liu |
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| Affiliation: | 1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No.?1 Beichen West Road, Chaoyang District, Beijing 100101, P.?R. China, (phone/fax: +86‐10‐64806074);2. State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, No.?1 Beichen West Road, Chaoyang District, Beijing 100101, P.?R. China |
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| Abstract: | A new cochlioquinone derivative, cochlioquinone F ( 1 ), as well as three known compounds, anhydrocochlioquinone A ( 2 ), isocochlioquinone A ( 3 ), and isocochlioquinone C ( 4 ), were isolated from the PDB (potato dextrose broth) culture of the phytopathogenic fungus Bipolaris luttrellii. The structure of 1 was elucidated on the basis of NMR techniques. The apoptosis‐inducing effects of compounds 1 – 4 were evaluated against HCT116 cancer cells. Compound 2 exhibited the strongest activity in inducing apoptosis on HCT116 cells within the range of 10–30 μM . In addition, the caspase activation, the release of cytochrome c from mitochondria, and the downregulation of Bcl‐2 protein in HCT116 cells treated with compound 2 were detected. |
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| Keywords: | Cochlioquinone derivatives Bipolaris luttrellii Apoptosis‐inducing effect |
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