| 肠内营养联合益生菌对重症脑卒中伴胃肠功能障碍患者肠黏膜屏障的保护作用 |
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| 引用本文： | 彭建红, 韩莉, 邵爱民. 肠内营养联合益生菌对重症脑卒中伴胃肠功能障碍患者肠黏膜屏障的保护作用[J]. 中国微生态学杂志, 2021, 33(6): 704-707. doi: 10.13381/j.cnki.cjm.202106018 |
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| 作者姓名： | 彭建红 韩莉 邵爱民 |
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| 作者单位： | 临海市第一人民医院神经内科,浙江 317000;台州医院神经内科 |
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| 摘 要： | 目的 探讨肠内营养联合益生菌对重症脑卒中伴胃肠功能障碍患者肠黏膜屏障的保护作用,为该类患者的治疗提供参考.方法 选择2016年1月至2019年7月于我院住院的84例重症脑卒中伴胃肠功能障碍患者为研究对象,根据肠内营养支持时是否添加益生菌将患者分为联用组和单用组,各42例.两组患者均予控制颅内压、营养脑细胞、保护胃黏膜和...
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| 关 键 词： | 重症脑卒中 肠内营养 益生菌 肠黏膜屏障 营养状态 胃肠道并发症 |
Protective effect of probiotics combined with enteral nutrition on intestinal mucosal barrier in patients with severe stroke concomitant with gastrointestinal dysfunction |
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| PENG Jianhong, HAN Li, SHAO Aimin. Protective effect of probiotics combined with enteral nutrition on intestinal mucosal barrier in patients with severe stroke concomitant with gastrointestinal dysfunction[J]. Chinese Journal of Microecology, 2021, 33(6): 704-707. doi: 10.13381/j.cnki.cjm.202106018 |
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| Authors: | PENG Jianhong HAN Li SHAO Aimin |
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| Affiliation: | Department of Neurology, the First People's Hospital of Linhai, Linhai, Zhejiang 317000, China |
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| Abstract: | Objective To explore the protective effect of probiotics combined with enteral nutrition on intestinal mucosal barrier in patients with severe stroke (SS) concomitant with gastrointestinal dysfunction (GD) and provide a reference for the treatment. Methods A total of 84 patients with SS concomitant with GD who were hospitalized in our hospital from January 2016 to July 2019 were selected. According to whether probiotics were added during enteral nutrition, they were divided into combination group or single drug group, with 42 cases in each group. The patients in two groups were given conventional treatments. The patients in single drug group was additionally given enteral nutrition treatment, while the patients in combination group was given 630 mg of viable Bifidobacteria capsules via nasal feeding, bid for 7 days. The nutritional status indicators [serum albumin (Alb), hemoglobin (Hb) and transferrin (TRF)], intestinal mucosal barrier indicators [serum diamine oxidase (DAO), procalcitonin (PCT)] and gastrointestinal complications were compared between two groups before and after treatment. Results After 7 days′ treatment, the levels of serum Alb, Hb and TRF in two groups were significantly lower, and the declines were more significant in single drug group than those in combination group (all P2=4.09, PConclusion Probiotics combined with enteral nutrition for patients with severe stroke concomitant with gastrointestinal dysfunction can improve the intestinal mucosal barrier function, reduce the occurrence of gastrointestinal complications, improve the tolerance of enteral nutrition, and thereby improve the patients′ nutritional status. |
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| Keywords: | Severe stroke Enteral nutrition Probiotics Intestinal mucosal barrier Nutritional status Gastrointestinal complications |
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