Regulation of the Chlamydia trachomatis histone H1-like protein Hc2 is IspE dependent and IhtA independent |
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| Authors: | Grieshaber Nicole A Sager Janet Burgess Dooley Cheryl A Hayes Stanley F Hackstadt Ted |
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| Affiliation: | Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. |
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| Abstract: | The chlamydial histone-like proteins, Hc1 and Hc2, function as global regulators of chromatin structure and gene expression. Hc1 and Hc2 expression and activity are developmentally regulated. A small metabolite that disrupts Hc1 interaction with DNA also disrupts Hc2 interactions; however, the small regulatory RNA that inhibits Hc1 translation is specific to Hc1. |
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